Nuclear receptor crosstalk can be defined as the interplay between different nuclear
receptors or between their overlapping signalling pathways. A subset of nuclear receptors …

Transcriptional control of cellular energy metabolic pathways is achieved by the coordinated
action of numerous transcription factors and associated coregulators. Several members of …

Background Sirtuin 3 (SIRT3) is one of the seven mammalian sirtuins, which are homologs
of the yeast Sir2 gene. SIRT3 is the only sirtuin with a reported association with the human …

The estrogen-related receptors (ERRs) comprise a small group of orphan nuclear receptor
transcription factors. The ERRα and ERRγ isoforms play a central role in the regulation of …

According to the World Health Organization (WHO) polycystic ovary syndrome (PCOS)
occurs in 4–8% of women worldwide. The prevalence of PCOS in Indian adolescents is …

Estrogen receptor related receptor (ERR) α was one of the first identified (1988) orphan
nuclear receptors. Many of the orphan receptors identified after ERRα were deorphanized in …

Sirt3 (silent mating type information regulation 2, homolog 3), a member of the sirtuin family
of protein deacetylases with multiple actions on metabolism and gene expression is …

The identification of the estrogen-related receptors (ERRs) as the first orphan nuclear
receptors ignited a new era in molecular endocrinology, which led to the discovery of new …

Mitochondrial dysfunction contributes to the etiology of numerous diseases. Consequently,
improving our knowledge of how to modulate mitochondrial activity is of considerable …

The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor (NR) that
significantly influences cellular metabolism. ESRRA is predominantly expressed in …