Growth hormone and insulin-like growth factor 1 regulation of nonalcoholic fatty liver disease
LE Dichtel, J Cordoba-Chacon… - The Journal of Clinical …, 2022 - academic.oup.com
Patients with obesity have a high prevalence of nonalcoholic fatty liver disease (NAFLD),
representing a spectrum of simple steatosis to nonalcoholic steatohepatitis (NASH), without …
representing a spectrum of simple steatosis to nonalcoholic steatohepatitis (NASH), without …
Programming of metabolism by adipokines during development
J Donato Jr - Nature Reviews Endocrinology, 2023 - nature.com
The intrauterine and early postnatal periods represent key developmental stages in which
an organism is highly susceptible to being permanently influenced by maternal factors and …
an organism is highly susceptible to being permanently influenced by maternal factors and …
Characterization of the metabolic differences between male and female C57BL/6 mice
Aims The present study aims to compare the responses between male and female C57BL/6
mice to multiple metabolic challenges to understand the importance of sex in the control of …
mice to multiple metabolic challenges to understand the importance of sex in the control of …
[HTML][HTML] NTS catecholamine neurons mediate hypoglycemic hunger via medial hypothalamic feeding pathways
Glucose is the essential energy source for the brain, whose deficit, triggered by energy
deprivation or therapeutic agents, can be fatal. Increased appetite is the key behavioral …
deprivation or therapeutic agents, can be fatal. Increased appetite is the key behavioral …
Central regulation of metabolism by growth hormone
Growth hormone (GH) is secreted by the pituitary gland, and in addition to its classical
functions of regulating height, protein synthesis, tissue growth, and cell proliferation, GH …
functions of regulating height, protein synthesis, tissue growth, and cell proliferation, GH …
Growth hormone action in somatostatin neurons regulates anxiety and fear memory
WO Dos Santos, VAL Juliano, FM Chaves… - Journal of …, 2023 - Soc Neuroscience
Dysfunctions in growth hormone (GH) secretion increase the prevalence of anxiety and
other neuropsychiatric diseases. GH receptor (GHR) signaling in the amygdala has been …
other neuropsychiatric diseases. GH receptor (GHR) signaling in the amygdala has been …
Mice with gene alterations in the GH and IGF family
Much of our understanding of GH's action stems from animal models and the generation and
characterization of genetically altered or modified mice. Manipulation of genes in the …
characterization of genetically altered or modified mice. Manipulation of genes in the …
New findings on brain actions of growth hormone and potential clinical implications
J Donato Jr, JJ Kopchick - Reviews in Endocrine and Metabolic Disorders, 2024 - Springer
Growth hormone (GH) is secreted by somatotropic cells of the anterior pituitary gland. The
classical effects of GH comprise the stimulation of cell proliferation, tissue and body growth …
classical effects of GH comprise the stimulation of cell proliferation, tissue and body growth …
Melanocortin-3 receptor expression in AgRP neurons is required for normal activation of the neurons in response to energy deficiency
Summary The melanocortin-3 receptor (MC3R) is a negative regulator of the central
melanocortin circuitry via presynaptic expression on agouti-related protein (AgRP) nerve …
melanocortin circuitry via presynaptic expression on agouti-related protein (AgRP) nerve …
Understanding the role of growth hormone in situations of metabolic stress
Growth hormone (GH) is secreted by the anterior pituitary gland and plays a key role in
controlling tissue and body growth. While basal GH secretion is considerably reduced along …
controlling tissue and body growth. While basal GH secretion is considerably reduced along …