The muscular dystrophies are inherited myogenic disorders characterised by progressive
muscle wasting and weakness of variable distribution and severity. They can be subdivided …

The X-linked muscle-wasting disease Duchenne muscular dystrophy is caused by mutations
in the gene encoding dystrophin. There is currently no effective treatment for the disease; …

Muscular dystrophy includes a diverse group of inherited muscle diseases characterized by
wasting and weakness of skeletal muscle. Mutations in dysferlin are linked to two clinically …

Amplification of the gene encoding the ErbB2 (Her2/neu) receptor tyrosine kinase is critical
for the progression of several forms of breast cancer. In a large-scale clinical trial, treatment …

The dystrophin glycoprotein complex (DGC) is a specialization of cardiac and skeletal
muscle membrane. This large multicomponent complex has both mechanical stabilizing and …

▪ Abstract Striated muscle is an intricate, efficient, and precise machine that contains
complex interconnected cytoskeletal networks critical for its contractile activity. The …

Dynamic membrane repair is essential not only for long-term maintenance of cellular
integrity but also for recovery from acute cell injury. While compromised membrane repair …

Muscular dystrophies represent a heterogeneous group of disorders, which have been
largely classified by clinical phenotype. In the last 10 years, identification of novel skeletal …

Cardiomyopathies are disorders affecting heart muscle that usually result in inadequate
pumping of the heart. They are the most common cause of heart failure and each year kill …

Mutations of different components of the dystrophin–glycoprotein complex (DGC) cause
muscular dystrophies that vary in terms of severity, age of onset, and selective involvement …