Acute kidney injury (AKI) arising from diverse etiologies is characterized by mitochondrial
dysfunction. The peroxisome proliferator-activated receptor γ coactivator-1alpha (PGC1α), a …

Preclinical models of human disease provide powerful tools for therapeutic discovery but
have limitations. This problem is especially apparent in the field of acute kidney injury (AKI) …

Kidney fibrosis is the unavoidable consequence of chronic kidney disease irrespective of the
primary underlying insult. It is a complex phenomenon governed by the interplay between …

Apoptotic cells are rapidly engulfed and degraded by phagocytes through efferocytosis.
Efferocytosis is a highly regulated process. It is triggered upon the activation of caspase …

Chronic kidney disease and acute kidney injury have traditionally been considered as
separate entities with different etiologies. This view has changed in recent years, with …

Importance Cardiometabolic parameters are established risk factors for COVID-19 severity.
The identification of causal or protective biomarkers for COVID-19 severity may facilitate the …

Chronic kidney disease of unknown etiology (CKDu) is an emerging global concern
affecting several agricultural communities in the Americas and South Asia. Environmental …

Acute kidney injury (AKI) is defined by a rapid decline in renal function. Regardless of the
initial cause of injury, the influx of immune cells is a common theme during AKI. While an …

Protease-activated receptor-2 (PAR2), which belongs to a specific class of the G-protein-
coupled receptors, is central to several inflammation processes. However, the precise …

One of the most widely used UV filters, 2-ethylhexyl-4-methoxycinnamate (EHMC), has been
widely detected in the environment. While its endocrine disruption potential has often been …