Disruption of epithelial barriers is a key pathogenic event of mucosal inflammation: It ignites
the exaggerated immune response and accelerates tissue damage. Loss of barrier function …

Myosins constitute a superfamily of actin-based molecular motor proteins that mediates a
variety of cellular activities including muscle contraction, cell migration, intracellular …

Dysregulated function of Th17 cells has implications in immunodeficiencies and
autoimmune disorders. Th17 cell differentiation is orchestrated by a complex network of …

Inguinal hernias are some of the most frequently diagnosed conditions in clinical practice
and inguinal hernia repair is the most common procedure performed by general surgeons …

Dietary sodium affects blood pressure (BP) and vascular function. Animal studies suggest
epigenetic changes (eg, DNA methylation) are involved. We hypothesized that sodium …

The gut microbiota is a crucial link between diet and cardiovascular disease (CVD). Using
fecal metaproteomics, a method that concurrently captures human gut and microbiome …

Inflammatory bowel diseases (IBD: Crohn's disease and ulcerative colitis) are becoming
common around the world without a cure. Animal models of colitis have become …

This study aimed to investigate the expression pattern of spermatogenesis associated
protein 6 (SPATA6) in Hu sheep testis and to ascertain the effects of SPATA6 on sheep …

Proper embryonic and postnatal skeletal development require coordination of myriad
complex molecular mechanisms. Disruption of these processes, through genetic mutation …

The gastrointestinal system digests and absorbs nutrients while integrating exogenous and
endogenous signals that contribute to create immune tolerance. Epithelial cells forming the …