Rationale. The developmental history and application of the 5-choice serial reaction time
task (5CSRTT) for measuring effects of drugs and other manipulations on attentional …

Cognitive deficits in schizophrenia remain an unmet clinical need. Improved understanding
of the neuro-and psychopathology of these deficits depends on the availability of carefully …

Addictions are often characterized as forms of impulsive behavior. That said, it is often noted
that impulsivity is a multidimensional construct, spanning several psychological domains …

Impulsivity, broadly defined as action without foresight, is a component of numerous
psychiatric illnesses including attention deficit/hyperactivity disorder (ADHD), mania and …

A growing body of preclinical evidence indicates that addiction to cocaine is associated with
neuroadaptive changes in frontostriatal brain systems. Human studies in cocaine-dependent …

It is becoming increasingly apparent that multiple functions of the frontal cortex such as
inhibitory control and executive attention are likely sustained by its functionally distinct and …

A comparative and integrated account is provided of the evidence that implicates
frontostriatal systems in neurodegenerative and neuropsychiatric disorders. Specifically, we …

We review drug addiction from the perspective of the hypothesis that drugs of abuse interact
with distinct brain memory systems. We focus on emotional and procedural forms of memory …

The stop-signal reaction-time (SSRT) task measures inhibition of a response that has
already been initiated, that is, the ability to stop. Human subjects classified as “impulsive,” for …

Impulsive acts and decisions are a part of everyday normal behavior. However, in its
pathological forms, impulsivity can be a debilitating disorder often associated with a number …