Redox reactions are of high fundamental and practical interest since they are involved in
both normal physiology and the pathogenesis of various diseases. However, this area of …

Staphylococcus aureus is a major human pathogen, which encounters reactive oxygen,
nitrogen, chlorine, electrophile and sulfur species (ROS, RNS, RCS, RES and RSS) by the …

The prevalence of methicillin-resitant Staphylococcus aureus (MRSA) in hospitals and the
community poses an increasing health burden, which requires the discovery of alternative …

Low molecular weight (LMW) thiols contain reducing sulfhydryl groups that are important for
maintaining antioxidant defense in the cell. Aside from the traditional roles of LMW thiols as …

The neutrophil phagosome is one of the most hostile environments that bacteria must face
and overcome if they are to succeed as pathogens. Targeting bacterial defense mechanisms …

Staphylococcus aureus is a major human pathogen, which causes life-threatening systemic
and chronic infections and rapidly acquires resistance to multiple antibiotics. Thus, new …

Abstract Low-molecular-weight (LMW) thiols are produced in all living cells in different forms
and concentrations. Glutathione (GSH), coenzyme A (CoASH), bacillithiol (BSH), mycothiol …

Structural studies show that enzymes have a limited number of unique folds, although
structurally related enzymes have evolved to perform a large variety of functions. In this …

Purpose Deinococcus radiodurans is an extremely radioresistant bacterium characterized
by D10 of 10 kGy, and able to grow luxuriantly under chronic ionizing radiation of 60 Gy/h …

Reactive oxygen species (ROS) play a crucial role in the cellular defense against S. aureus,
as evidenced by the importance of this pathogen in patients lacking the ROS-generating …