Autism is a heterogeneous neurodevelopmental disorder of unknown aetiology that affects 1
in 100–150 individuals. Diagnosis is based on three categories of behavioural criteria …

Choline is an essential nutrient for humans. It is a precursor of membrane phospholipids (eg,
phosphatidylcholine (PC)), the neurotransmitter acetylcholine, and via betaine, the methyl …

Autism is diagnosed by three major symptom categories: unusual reciprocal social
interactions, impaired communication, and repetitive behaviors with restricted interests …

Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by three
core symptoms that include social interaction deficits, cognitive inflexibility, and …

BTBR T+ tf/J (BTBR) is an inbred mouse strain that displays social abnormalities and
repetitive behaviors analogous to the first and third diagnostic symptoms of autism. Here we …

The reproducibility crisis (or replication crisis) in biomedical research is a particularly
existential and under-addressed issue in the field of behavioral neuroscience, where, in …

Animal models provide preclinical tools to investigate the causal role of genetic mutations
and environmental factors in the etiology of autism spectrum disorder (ASD). Knockout and …

Autism is a neurodevelopmental disorder characterized by abnormal reciprocal social
interactions, communication deficits, and repetitive behaviors with restricted interests. BTBR …

Comprehensive behavioral analyses of transgenic and knockout mice have successfully
identified the functional roles of many genes in the brain. Over the past 10 years, strategies …

BTBR T+ tf/J (BTBR) is an inbred mouse strain that displays social deficits and repetitive
behaviors analogous to the first and third diagnostic symptoms of autism. We previously …