Tau imaging in neurodegenerative diseases using positron emission tomography
Abstract Purpose of Review Abnormal accumulation of tau protein is the main hallmark of
tauopathies and is closely associated with neurodegeneration and cognitive impairment …
tauopathies and is closely associated with neurodegeneration and cognitive impairment …
Cross-interaction of tau PET tracers with monoamine oxidase B: evidence from in silico modelling and in vivo imaging
Purpose Several tracers have been designed for tracking the abnormal accumulation of tau
pathology in vivo. Recently, concerns have been raised about the sources of off-target …
pathology in vivo. Recently, concerns have been raised about the sources of off-target …
[18F]THK-5351 PET imaging in early-stage semantic variant primary progressive aphasia: a report of two cases and a literature review
R Kobayashi, H Hayashi, S Kawakatsu, A Ishiki… - BMC neurology, 2018 - Springer
Background Semantic variant primary progressive aphasia (svPPA) is a subtype of primary
progressive aphasia characterized by two-way anomia and disturbance in word …
progressive aphasia characterized by two-way anomia and disturbance in word …
Early-phase [18F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury
L Beyer, A Nitschmann, H Barthel… - European journal of …, 2020 - Springer
Purpose Second-generation tau radiotracers for use with positron emission tomography
(PET) have been developed for visualization of tau deposits in vivo. For several β-amyloid …
(PET) have been developed for visualization of tau deposits in vivo. For several β-amyloid …
Comparison of regional flortaucipir PET with quantitative tau immunohistochemistry in three subjects with Alzheimer's disease pathology: a clinicopathological study
Background The objective of this study was to make a quantitative comparison of flortaucipir
PET retention with pathological tau and β-amyloid across a range of brain regions at …
PET retention with pathological tau and β-amyloid across a range of brain regions at …
Dual tracer tau PET imaging reveals different molecular targets for 11C-THK5351 and 11C-PBB3 in the Alzheimer brain
K Chiotis, P Stenkrona, O Almkvist, V Stepanov… - European Journal of …, 2018 - Springer
Purpose Several tau PET tracers have been developed, but it remains unclear whether they
bind to the same molecular target on the heterogeneous tau pathology. In this study we …
bind to the same molecular target on the heterogeneous tau pathology. In this study we …
Longitudinal tau and metabolic PET imaging in relation to novel CSF tau measures in Alzheimer's disease
Purpose Studies comparing CSF and PET tau biomarkers have included only commercial
CSF assays examining specific phosphorylation sites (eg threonine 181, P-tau 181p) and …
CSF assays examining specific phosphorylation sites (eg threonine 181, P-tau 181p) and …
PET molecular imaging for pathophysiological visualization in Alzheimer's disease
Alzheimer's disease (AD) is the most common dementia worldwide. The exact etiology of AD
is unclear as yet, and no effective treatments are currently available, making AD a …
is unclear as yet, and no effective treatments are currently available, making AD a …
Monoamine oxidase binding not expected to significantly affect [18F]flortaucipir PET interpretation
JP Wright, JR Goodman, YG Lin, BP Lieberman… - European Journal of …, 2022 - Springer
Abstract Purpose [18F]-labeled positron emission tomography (PET) radioligands permit in
vivo assessment of Alzheimer's disease biomarkers, including aggregated neurofibrillary tau …
vivo assessment of Alzheimer's disease biomarkers, including aggregated neurofibrillary tau …
Differences in gray and white matter 18F-THK5351 uptake between behavioral-variant frontotemporal dementia and other dementias
Purpose We investigated the regional distribution of 18 F-THK5351 uptake in gray (GM) and
white matter (WM) in patients with behavioral-variant frontotemporal dementia (bvFTD) and …
white matter (WM) in patients with behavioral-variant frontotemporal dementia (bvFTD) and …