Tumor microenvironment in pancreatic cancer pathogenesis and therapeutic resistance

MH Sherman, GL Beatty - Annual Review of Pathology …, 2023 - annualreviews.org
Pancreatic ductal adenocarcinoma (PDAC) features a prominent stromal microenvironment
with remarkable cellular and spatial heterogeneity that meaningfully impacts disease …

Inflammation and liver cancer: molecular mechanisms and therapeutic targets

YM Yang, SY Kim, E Seki - Seminars in liver disease, 2019 - thieme-connect.com
Hepatocellular carcinoma (HCC) is associated with chronic inflammation and fibrosis arising
from different etiologies, including hepatitis B and C and alcoholic and nonalcoholic fatty …

[HTML][HTML] Hyperinsulinemia in obesity, inflammation, and cancer

AMY Zhang, EA Wellberg, JL Kopp… - … & metabolism journal, 2021 - synapse.koreamed.org
The relative insufficiency of insulin secretion and/or insulin action causes diabetes.
However, obesity and type 2 diabetes mellitus can be associated with an absolute increase …

Emerging cancer trends among young adults in the USA: analysis of a population-based cancer registry

H Sung, RL Siegel, PS Rosenberg… - The Lancet Public …, 2019 - thelancet.com
Background Cancer trends in young adults, often under 50 years, reflect recent changes in
carcinogenic exposures, which could foreshadow the future overall disease burden …

Diabetes, pancreatogenic diabetes, and pancreatic cancer

DK Andersen, M Korc, GM Petersen, G Eibl, D Li… - Diabetes, 2017 - Am Diabetes Assoc
The relationships between diabetes and pancreatic ductal adenocarcinoma (PDAC) are
complex. Longstanding type 2 diabetes (T2DM) is a risk factor for pancreatic cancer, but …

Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation

AMY Zhang, YH Xia, JSH Lin, KH Chu, WCK Wang… - Cell Metabolism, 2023 - cell.com
The rising pancreatic cancer incidence due to obesity and type 2 diabetes is closely tied to
hyperinsulinemia, an independent cancer risk factor. Previous studies demonstrated …

Pancreatic cancer

J Kleeff, M Korc, M Apte, C La Vecchia… - Nature reviews Disease …, 2016 - nature.com
Pancreatic cancer is a major cause of cancer-associated mortality, with a dismal overall
prognosis that has remained virtually unchanged for many decades. Currently, prevention or …

[HTML][HTML] Worldwide flavor enhancer monosodium glutamate combined with high lipid diet provokes metabolic alterations and systemic anomalies: An overview

A Banerjee, S Mukherjee, BK Maji - Toxicology Reports, 2021 - Elsevier
In this fast-food era, people depend on ready-made foods and engage in minimal physical
activities that ultimately change their food habits. Majorities of such foods have harmful …

[图书][B] Food lipids: chemistry, nutrition, and biotechnology

CC Akoh - 2017 - taylorfrancis.com
Maintaining the high standards that made the previous editions such well-respected and
widely used references, Food Lipids: Chemistry, Nutrition, and Biotechnology, Fourth Edition …

Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ

Y Liu, Y Deguchi, D Wei, F Liu, MJ Moussalli… - Nature …, 2022 - nature.com
Pancreatic intraepithelial neoplasia (PanIN) is a precursor of pancreatic ductal
adenocarcinoma (PDAC), which commonly occurs in the general populations with aging …