Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Synaptic AMPA receptor composition in development, plasticity and disease
JM Henley, KA Wilkinson - Nature Reviews Neuroscience, 2016 - nature.com
AMPA receptors (AMPARs) are assemblies of four core subunits, GluA1–4, that mediate
most fast excitatory neurotransmission. The component subunits determine the functional …
most fast excitatory neurotransmission. The component subunits determine the functional …
Glutamate receptor ion channels: structure, regulation, and function
The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
[HTML][HTML] The expanding social network of ionotropic glutamate receptors: TARPs and other transmembrane auxiliary subunits
AC Jackson, RA Nicoll - Neuron, 2011 - cell.com
Ionotropic glutamate receptors (iGluRs) underlie rapid, excitatory synaptic signaling
throughout the CNS. After years of intense research, our picture of iGluRs has evolved from …
throughout the CNS. After years of intense research, our picture of iGluRs has evolved from …
Cargo capture and bulk flow in the early secretory pathway
C Barlowe, A Helenius - Annual review of cell and …, 2016 - annualreviews.org
Transport of newly synthesized proteins from the endoplasmic reticulum (ER) to the Golgi
complex is highly selective. As a general rule, such transport is limited to soluble and …
complex is highly selective. As a general rule, such transport is limited to soluble and …
Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors
J Schwenk, N Harmel, G Zolles, W Bildl, A Kulik… - Science, 2009 - science.org
Glutamate receptors of the AMPA-subtype (AMPARs), together with the transmembrane
AMPAR regulatory proteins (TARPs), mediate fast excitatory synaptic transmission in the …
AMPAR regulatory proteins (TARPs), mediate fast excitatory synaptic transmission in the …
Protein sorting receptors in the early secretory pathway
J Dancourt, C Barlowe - Annual review of biochemistry, 2010 - annualreviews.org
Estimates based on proteomic analyses indicate that a third of translated proteins in
eukaryotic genomes enter the secretory pathway. After folding and assembly of nascent …
eukaryotic genomes enter the secretory pathway. After folding and assembly of nascent …
Exploring the function of cell shape and size during mitosis
Dividing cells almost always adopt a spherical shape. This is true of most eukaryotic cells
lacking a rigid cell wall and is observed in tissue culture and single-celled organisms, as …
lacking a rigid cell wall and is observed in tissue culture and single-celled organisms, as …
Cornichon proteins determine the subunit composition of synaptic AMPA receptors
BE Herring, Y Shi, YH Suh, CY Zheng, SM Blankenship… - Neuron, 2013 - cell.com
Summary Cornichon-2 and cornichon-3 (CNIH-2/-3) are AMPA receptor (AMPAR) binding
proteins that promote receptor trafficking and markedly slow AMPAR deactivation in …
proteins that promote receptor trafficking and markedly slow AMPAR deactivation in …
An ER assembly line of AMPA-receptors controls excitatory neurotransmission and its plasticity
J Schwenk, S Boudkkazi, MK Kocylowski, A Brechet… - Neuron, 2019 - cell.com
Excitatory neurotransmission and its activity-dependent plasticity are largely determined by
AMPA-receptors (AMPARs), ion channel complexes whose cell physiology is encoded by …
AMPA-receptors (AMPARs), ion channel complexes whose cell physiology is encoded by …