Human exposure to aluminium

C Exley - Environmental Science: Processes & Impacts, 2013 - pubs.rsc.org
Human activities have circumvented the efficient geochemical cycling of aluminium within
the lithosphere and therewith opened a door, which was previously only ajar, onto the biotic …

Hepatic response to aluminum toxicity: dyslipidemia and liver diseases

RJ Mailloux, J Lemire, VD Appanna - Experimental cell research, 2011 - Elsevier
Aluminum (Al) is a metal toxin that has been implicated in the etiology of a number of
diseases including Alzheimer's, Parkinson's, dialysis encephalopathy, and osteomalacia. Al …

Pro-oxidant activity of aluminum: promoting the Fenton reaction by reducing Fe (III) to Fe (II)

F Ruipérez, JI Mujika, JM Ugalde, C Exley… - Journal of inorganic …, 2012 - Elsevier
The possibility for an Al-superoxide complex to reduce Fe (III) to Fe (II), promoting oxidative
damage through the Fenton reaction, is investigated using highly accurate ab initio methods …

The binding, transport and fate of aluminium in biological cells

C Exley, MJ Mold - Journal of Trace Elements in Medicine and Biology, 2015 - Elsevier
Aluminium is the most abundant metal in the Earth's crust and yet, paradoxically, it has no
known biological function. Aluminium is biochemically reactive, it is simply that it is not …

Pro-oxidant activity of aluminum: stabilization of the aluminum superoxide radical ion

JI Mujika, F Ruipérez, I Infante, JM Ugalde… - The Journal of …, 2011 - ACS Publications
The pro-oxidant activity of aluminum, a nonredox metal, through superoxide formation is
studied by theoretical methods, determining the ESR g-tensor values of O2•–with a variety of …

[HTML][HTML] Aluminium in biological environments: a computational approach

JI Mujika, E Rezabal, JM Mercero, F Ruipérez… - Computational and …, 2014 - Elsevier
The increased availability of aluminium in biological environments, due to human
intervention in the last century, raises concerns on the effects that this so far “excluded from …

Molecular dynamics simulations of iron-and aluminum-loaded serum transferrin: protonation of Tyr188 is necessary to prompt metal release

JI Mujika, B Escribano, E Akhmatskaya, JM Ugalde… - Biochemistry, 2012 - ACS Publications
Serum transferrin (sTf) carries iron in blood serum and delivers it into cells by receptor-
mediated endocytosis. The protein can also bind other metals, including aluminum. The …

Protective and prophylactic effects of chlorogenic acid on aluminum-induced acute hepatotoxicity and hematotoxicity in mice

D Cheng, X Zhang, L Xu, X Li, L Hou… - Chemico-biological …, 2017 - Elsevier
The possible health impact of the exposures to Al from environment would be inevitable for
humans. Using chelating agents and natural antioxidants against Al-induced biotoxicity …

A QM/MM study of the complexes formed by aluminum and iron with serum transferrin at neutral and acidic pH

JI Mujika, X López, E Rezabal, R Castillo… - Journal of inorganic …, 2011 - Elsevier
Serum transferrin (sTf) transports iron in serum and internalizes in cells via receptor
mediated endocytosis. Additionally, sTf has been identified as the predominant aluminum …

Effect of aluminum (Al) speciation on erythrocytic antioxidant defense process: Correlations between lipid membrane peroxidation and morphological characteristics

D Cheng, J Tang, X Wang, X Zhang, S Wang - … and Environmental Safety, 2018 - Elsevier
Al contamination becomes a growing problem in human society. Accumulation of Al in blood
could destroy the structure and disorder function of erythrocyte, and finally cause blood …