Synthesis and pharmacological activities of pyrazole derivatives: A review
Pyrazole and its derivatives are considered a pharmacologically important active scaffold
that possesses almost all types of pharmacological activities. The presence of this nucleus in …
that possesses almost all types of pharmacological activities. The presence of this nucleus in …
Methylglyoxal and its adducts: Induction, repair, and association with disease
SWT Lai, EDJ Lopez Gonzalez, T Zoukari… - Chemical research in …, 2022 - ACS Publications
Metabolism is an essential part of life that provides energy for cell growth. During metabolic
flux, reactive electrophiles are produced that covalently modify macromolecules, leading to …
flux, reactive electrophiles are produced that covalently modify macromolecules, leading to …
The therapeutic voyage of pyrazole and its analogs: a review
Pyrazole, a five membered heteroaromatic ring with two nitrogen atoms is of immense
significance. Presence of this nucleus in the pharmacological agents of diverse therapeutic …
significance. Presence of this nucleus in the pharmacological agents of diverse therapeutic …
Targeting the receptor for advanced glycation endproducts (RAGE): a medicinal chemistry perspective
S Bongarzone, V Savickas, F Luzi… - Journal of medicinal …, 2017 - ACS Publications
The receptor for advanced glycation endproducts (RAGE) is an ubiquitous, transmembrane,
immunoglobulin-like receptor that exists in multiple isoforms and binds to a diverse range of …
immunoglobulin-like receptor that exists in multiple isoforms and binds to a diverse range of …
All the “RAGE” in lung disease: The receptor for advanced glycation endproducts (RAGE) is a major mediator of pulmonary inflammatory responses
EA Oczypok, TN Perkins, TD Oury - Paediatric respiratory reviews, 2017 - Elsevier
The receptor for advanced glycation endproducts (RAGE) is a pro-inflammatory pattern
recognition receptor (PRR) that has been implicated in the pathogenesis of numerous …
recognition receptor (PRR) that has been implicated in the pathogenesis of numerous …
Molecular characteristics of RAGE and advances in small-molecule inhibitors
HJ Kim, MS Jeong, SB Jang - International journal of molecular sciences, 2021 - mdpi.com
Receptor for advanced glycation end-products (RAGE) is a member of the immunoglobulin
superfamily. RAGE binds and mediates cellular responses to a range of DAMPs (damage …
superfamily. RAGE binds and mediates cellular responses to a range of DAMPs (damage …
The receptor for advanced glycation end products (RAGE) enhances autophagy and neutrophil extracellular traps in pancreatic cancer
BA Boone, L Orlichenko, NE Schapiro… - Cancer gene …, 2015 - nature.com
Neutrophil extracellular traps (NETs) are formed when neutrophils expel their DNA, histones
and intracellular proteins into the extracellular space or circulation .NET formation is …
and intracellular proteins into the extracellular space or circulation .NET formation is …
Advanced glycation end products (AGEs) and its receptor, RAGE, modulate age-dependent COVID-19 morbidity and mortality. A review and hypothesis
D Sellegounder, P Zafari, M Rajabinejad… - International …, 2021 - Elsevier
Abstract Coronavirus Disease 2019 (COVID-19), caused by the novel virus SARS-CoV-2, is
often more severe in older adults. Besides age, other underlying conditions such as obesity …
often more severe in older adults. Besides age, other underlying conditions such as obesity …
Receptor for advanced glycation end‐products: Biological significance and imaging applications
IT Dobrucki, A Miskalis, M Nelappana… - Wiley …, 2024 - Wiley Online Library
The receptor for advanced glycation end‐products (RAGE or AGER) is a transmembrane,
immunoglobulin‐like receptor that, due to its multiple isoform structures, binds to a diverse …
immunoglobulin‐like receptor that, due to its multiple isoform structures, binds to a diverse …
Synthesis, molecular docking and enzyme inhibitory approaches of some new chalcones engrafted pyrazole as potential antialzheimer, antidiabetic and antioxidant …
MS Islam, AM Al-Majid, EN Sholkamy, S Yousuf… - Journal of Molecular …, 2022 - Elsevier
About 25 chalcones engrafted pyrazole scaffold combined with benzothiophene and indole
moieties 5a-y were designed and constructed in two steps using readily available acetyl …
moieties 5a-y were designed and constructed in two steps using readily available acetyl …