Pyrazole and its derivatives are considered a pharmacologically important active scaffold
that possesses almost all types of pharmacological activities. The presence of this nucleus in …

Metabolism is an essential part of life that provides energy for cell growth. During metabolic
flux, reactive electrophiles are produced that covalently modify macromolecules, leading to …

Pyrazole, a five membered heteroaromatic ring with two nitrogen atoms is of immense
significance. Presence of this nucleus in the pharmacological agents of diverse therapeutic …

The receptor for advanced glycation endproducts (RAGE) is an ubiquitous, transmembrane,
immunoglobulin-like receptor that exists in multiple isoforms and binds to a diverse range of …

The receptor for advanced glycation endproducts (RAGE) is a pro-inflammatory pattern
recognition receptor (PRR) that has been implicated in the pathogenesis of numerous …

Receptor for advanced glycation end-products (RAGE) is a member of the immunoglobulin
superfamily. RAGE binds and mediates cellular responses to a range of DAMPs (damage …

Neutrophil extracellular traps (NETs) are formed when neutrophils expel their DNA, histones
and intracellular proteins into the extracellular space or circulation .NET formation is …

Abstract Coronavirus Disease 2019 (COVID-19), caused by the novel virus SARS-CoV-2, is
often more severe in older adults. Besides age, other underlying conditions such as obesity …

The receptor for advanced glycation end‐products (RAGE or AGER) is a transmembrane,
immunoglobulin‐like receptor that, due to its multiple isoform structures, binds to a diverse …

About 25 chalcones engrafted pyrazole scaffold combined with benzothiophene and indole
moieties 5a-y were designed and constructed in two steps using readily available acetyl …