Background Beta-lactam antibiotics (βLA) are the most commonly used antibiotics in the
intensive care unit (ICU). ICU patients present many pathophysiological features that cause …

The rapid emergence and dissemination of antimicrobial-resistant microorganisms in ICUs
worldwide constitute a problem of crisis dimensions. The root causes of this problem are …

Antimicrobials are among the most important and commonly prescribed drugs in the
management of critically ill patients and beta-lactams are the most common antibiotic class …

Introduction: The pharmacokinetic/pharmacodynamic index determining β-lactam activity is
the percentage of the dosing interval (% T) during which their free serum concentration …

Many critically ill patients display a supraphysiological renal function with enhanced renal
perfusion and glomerular hyperfiltration. This phenomenon described as augmented renal …

Piperacillin-tazobactam is a potent β-lactam/β-lactamase inhibitor antibiotic commonly
prescribed in the intensive care unit setting. Admitted patients often show large variability in …

Therapeutic drug monitoring (TDM) of antibiotics is recommended and increasingly used in
critically ill patients to optimize target attainment and account for interpatient …

Purpose Adequate empirical antibiotic dose selection for critically ill burn patients is difficult
due to extreme variability in drug pharmacokinetics. Therapeutic drug monitoring (TDM) may …

Optimal loading doses of β-lactams to rapidly achieve adequate drug concentrations in
critically ill patients are unknown. This was a post-hoc analysis of a prospective study that …

Objectives This study aimed to describe the population pharmacokinetics (PK) of cefepime
during extracorporeal membrane oxygenation (ECMO) and through dosing simulations …