Boron-containing carbonic anhydrases inhibitors
S Giovannuzzi, A Nikitjuka, BRP Resende… - Bioorganic …, 2024 - Elsevier
Over the last decades, the medicinal chemistry of boron-based compounds has been
extensively explored, designing valuable small molecule drugs to tackle diseases and …
extensively explored, designing valuable small molecule drugs to tackle diseases and …
The inhibitory effect of boric acid on hypoxia-regulated tumour-associated carbonic anhydrase IX
Abstract Carbonic anhydrases (EC 4.2. 1.1) catalyse the reversible hydration of CO2 into
bicarbonate and protons. As a hypoxia-sensitive and tumour-associated isoform, isoform CA …
bicarbonate and protons. As a hypoxia-sensitive and tumour-associated isoform, isoform CA …
Halogenated boroxine increases propensity to apoptosis in leukemia (UT‐7) but not non‐tumor cells in vitro
A hallmark of the development of solid and hematological malignancies is the dysregulation
of apoptosis, which leads to an imbalance between cell proliferation, cell survival and death …
of apoptosis, which leads to an imbalance between cell proliferation, cell survival and death …
Novel boron‐containing compound, halogenated boroxine, induces selective cytotoxicity through apoptosis triggering in UT‐7 leukemia
Apoptosis induction is a promising approach in targeting tumor cells. As halogenated
boroxine (HB) shows antitumor activity, but its mechanism of action in hematological tumors …
boroxine (HB) shows antitumor activity, but its mechanism of action in hematological tumors …
Biochemical and histomorphological findings in Swiss Wistar rats treated with potential boron-containing therapeutic-K2 [B3O3F4OH]
Background Boron and boron containing compounds are known for their biological and
protective roles being non-toxic and non-mutagenic in low concentrations. Male rats were …
protective roles being non-toxic and non-mutagenic in low concentrations. Male rats were …
Bioflavonoids protect cells against halogenated boroxine-induced genotoxic damage by upregulation of hTERT expression
Plant bioflavonoids are widely present in the human diet and have various protective
properties. In this study, we have demonstrated the capacity of delphinidin and luteolin to …
properties. In this study, we have demonstrated the capacity of delphinidin and luteolin to …
Moderate Toxicity of Potential Boron-containing Therapeutic, Dipotassium-trioxohydroxytetrafl uorotriborate -K2(B3O3F4OH) in Rats and Mice
Biological activity of boron-containing compounds (BCCs) has been well-known. Growing
interest and numerous applications for BCCs have been reported. Boron and boron …
interest and numerous applications for BCCs have been reported. Boron and boron …
Halogenated Boroxine K2[B3O3F4OH] Modulates Metabolic Phenotype and Autophagy in Human Bladder Carcinoma 5637 Cell Line
Halogenated boroxine K2 [B3O3F4OH](HB), an inorganic derivative of cyclic anhydride of
boronic acid, is patented as a boron-containing compound with potential for the treatment of …
boronic acid, is patented as a boron-containing compound with potential for the treatment of …
New in vitro findings about halogenated boroxine cytotoxicity and deregulation of cell death-related genes in GR-M melanoma cells
Sažetak Anti-proliferative effects of halogenated boroxine–K2 (B3O3F4OH)(HB)–have been
confirmed in multiple cancer cell lines, including melanoma, but the exact mechanism of …
confirmed in multiple cancer cell lines, including melanoma, but the exact mechanism of …
[HTML][HTML] In silico prediction suggests inhibitory effect of halogenated boroxine on human catalase and carbonic anhydrase
T Corbo, A Kalajdzic, D Delic, S Suleiman… - Journal of Genetic …, 2022 - Elsevier
Background This research work included bioinformatics modeling of the dipotassium-
trioxohydroxytetrafluorotriborate-halogenated boroxine molecule, as well as simulation and …
trioxohydroxytetrafluorotriborate-halogenated boroxine molecule, as well as simulation and …