[HTML][HTML] The functional diversity of Aurora kinases: a comprehensive review
E Willems, M Dedobbeleer, M Digregorio, A Lombard… - Cell division, 2018 - Springer
Aurora kinases are serine/threonine kinases essential for the onset and progression of
mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit …
mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit …
[HTML][HTML] Aurora kinases: novel therapy targets in cancers
A Tang, K Gao, L Chu, R Zhang, J Yang, J Zheng - Oncotarget, 2017 - ncbi.nlm.nih.gov
Aurora kinases, a family of serine/threonine kinases, consisting of Aurora A (AURKA),
Aurora B (AURKB) and Aurora C (AURKC), are essential kinases for cell division via …
Aurora B (AURKB) and Aurora C (AURKC), are essential kinases for cell division via …
[HTML][HTML] AURKB promotes gastric cancer progression via activation of CCND1 expression
Aurora kinase B (AURKB) triggers the phosphorylation of serine 10 on histone H3
(H3S10ph), which is important for chromosome condensation and cytokinesis during mitosis …
(H3S10ph), which is important for chromosome condensation and cytokinesis during mitosis …
[HTML][HTML] The ins and outs of Aurora B inner centromere localization
S Hindriksen, SMA Lens, MA Hadders - Frontiers in cell and …, 2017 - frontiersin.org
Error-free chromosome segregation is essential for the maintenance of genomic integrity
during cell division. Aurora B, the enzymatic subunit of the Chromosomal Passenger …
during cell division. Aurora B, the enzymatic subunit of the Chromosomal Passenger …
[HTML][HTML] The phosphorylated form of the histone H2AX (γH2AX) in the brain from embryonic life to old age
A Merighi, N Gionchiglia, A Granato, L Lossi - Molecules, 2021 - mdpi.com
The γ phosphorylated form of the histone H2AX (γH2AX) was described more than 40 years
ago and it was demonstrated that phosphorylation of H2AX was one of the first cellular …
ago and it was demonstrated that phosphorylation of H2AX was one of the first cellular …
[HTML][HTML] Calcineurin-mediated dephosphorylation enhances the stability and transactivation of c-Myc
Abstract c-Myc, a transcription factor, induces cell proliferation and is often aberrantly or
highly expressed in cancers. However, molecular mechanisms underlying this aberrantly …
highly expressed in cancers. However, molecular mechanisms underlying this aberrantly …
[HTML][HTML] Aurora B tension sensing mechanisms in the kinetochore ensure accurate chromosome segregation
SL McVey, JK Cosby, NJ Nannas - International Journal of Molecular …, 2021 - mdpi.com
The accurate segregation of chromosomes is essential for the survival of organisms and
cells. Mistakes can lead to aneuploidy, tumorigenesis and congenital birth defects. The …
cells. Mistakes can lead to aneuploidy, tumorigenesis and congenital birth defects. The …
[HTML][HTML] Foxo1 promotes cancer cell growth through mdm2-mediated p53 degradation
FOXO1 is a transcription factor and potential tumor suppressor that is negatively regulated
downstream of PI3K-PKB/AKT signaling. Paradoxically, FOXO also promotes tumor growth …
downstream of PI3K-PKB/AKT signaling. Paradoxically, FOXO also promotes tumor growth …
FKBP51 and FKBP52 regulate androgen receptor dimerization and proliferation in prostate cancer cells
K Maeda, M Habara, M Kawaguchi… - Molecular …, 2022 - Wiley Online Library
The growth of prostate cancer is dependent on the androgen receptor (AR), which serves as
a ligand‐specific transcription factor. Although two immunophilins, FKBP51 and FKBP52 …
a ligand‐specific transcription factor. Although two immunophilins, FKBP51 and FKBP52 …
[HTML][HTML] Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer
The agonistic/antagonistic biocharacter of selective estrogen receptor modulators (SERMs)
can have therapeutic advantages, particularly in the case of premenopausal breast cancers …
can have therapeutic advantages, particularly in the case of premenopausal breast cancers …