Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine

R Radi - Proceedings of the National Academy of Sciences, 2018 - National Acad Sciences
Oxygen-derived free radicals and related oxidants are ubiquitous and short-lived
intermediates formed in aerobic organisms throughout life. These reactive species …

[HTML][HTML] Antioxidant therapy in cancer: Rationale and progress

M Luo, L Zhou, Z Huang, B Li, EC Nice, J Xu, C Huang - Antioxidants, 2022 - mdpi.com
Cancer is characterized by increased oxidative stress, an imbalance between reactive
oxygen species (ROS) and antioxidants. Enhanced ROS accumulation, as a result of …

[HTML][HTML] Construction of a two-dimensional artificial antioxidase for nanocatalytic rheumatoid arthritis treatment

B Yang, H Yao, J Yang, C Chen, J Shi - Nature Communications, 2022 - nature.com
Constructing nanomaterials mimicking the coordination environments of natural enzymes
may achieve biomimetic catalysis. Here we construct a two-dimensional (2D) metal-organic …

[HTML][HTML] European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

J Egea, I Fabregat, YM Frapart, P Ghezzi, A Görlach… - Redox biology, 2017 - Elsevier
Abstract The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …

Ochratoxin A: Toxicity, oxidative stress and metabolism

Y Tao, S Xie, F Xu, A Liu, Y Wang, D Chen… - Food and Chemical …, 2018 - Elsevier
Ochratoxin A (OTA) is a widespread mycotoxin commonly found as a corn contaminant. It
has been shown to be nephrotoxic, hepatotoxic, teratogenic and immunotoxic to several …

Ergothioneine–a diet‐derived antioxidant with therapeutic potential

B Halliwell, IK Cheah, RMY Tang - FEBS letters, 2018 - Wiley Online Library
Ergothioneine is a thiol/thione molecule synthesised only by some fungi and bacteria.
Nonetheless, it is avidly taken up from the diet by humans and other animals through a …

Catalysis and Electron Transfer in De Novo Designed Metalloproteins

KJ Koebke, TBJ Pinter, WC Pitts, VL Pecoraro - Chemical reviews, 2022 - ACS Publications
One of the hallmark advances in our understanding of metalloprotein function is showcased
in our ability to design new, non-native, catalytically active protein scaffolds. This review …

Mini-Review: Oxidative stress, redox stress or redox success?

JMC Gutteridge, B Halliwell - Biochemical and biophysical research …, 2018 - Elsevier
The first life forms evolved in a highly reducing environment. This reduced state is still
carried by cells today, which makes the concept of “reductive stress” somewhat redundant …

The superoxide radical switch in the biology of nitric oxide and peroxynitrite

L Piacenza, A Zeida, M Trujillo… - Physiological …, 2022 - journals.physiology.org
The free radical nitric oxide (· NO) is a key mediator in different physiological processes such
as vasodilation, neurotransmission, inflammation, and cellular immune responses, and thus …

Intracellular catalysis with selected metal complexes and metallic nanoparticles: advances toward the development of catalytic metallodrugs

JJ Soldevila-Barreda, N Metzler-Nolte - Chemical reviews, 2019 - ACS Publications
Platinum-containing drugs (eg, cisplatin) are among the most frequently used
chemotherapeutic agents. Their tremendous success has spurred research and …