The discovery of IgE represented a major breakthrough in allergy and asthma research,
whereas the clinical interest given to IgE in asthma has been blurred until the arrival of anti …

The nuclear factor-kappa B (NF-κB) signaling pathway is a multi-component pathway that
regulates the expression of hundreds of genes that are involved in diverse and key cellular …

Asthma and asthma-related traits are complex diseases with strong genetic and
environmental components. Rapid progress in asthma genetics has led to the identification …

High levels of serum IgE are considered markers of parasite and helminth exposure. In
addition, they are associated with allergic disorders, play a key role in anti-tumoral defence …

BACKGROUND: IgE production, a hallmark of asthma and atopic disease, may be under
genetic control. Genes of the IL-4 and IL-13 pathway, central for IgE regulation, have so far …

Asthma is the result of a complex interaction between environmental factors and genetic
variants that confer susceptibility. Studies of the genetics of asthma have previously been …

Immunoglobulin E (IgE) mediated immune responses seem to be directed against parasites
and neoplasms, but are best known for their involvement in allergies. The IgE network is …

Effector CD8+ T cells convert from IFN-γ+(Tc1) to IL-13+(Tc2) cells in the presence of IL-4.
Underlying regulatory mechanisms are not fully defined. Here, we show that addition of 1 …

Atopic dermatitis (AD), food allergy, allergic rhinitis, and asthma are common atopic
disorders of complex etiology. The frequently observed atopic march from early AD to …

Background Chromosome 17q21, harboring the orosomucoid 1-like 3 (ORMDL3) gene, has
been consistently associated with childhood asthma in genome-wide association studies …