Mito‐bomb: targeting mitochondria for cancer therapy

X Guo, N Yang, W Ji, H Zhang, X Dong… - Advanced …, 2021 - Wiley Online Library
Cancer has been one of the most common life‐threatening diseases for a long time.
Traditional cancer therapies such as surgery, chemotherapy (CT), and radiotherapy (RT) …

Targeting mitochondrial biogenesis with polyphenol compounds

L Chodari, M Dilsiz Aytemir, P Vahedi… - Oxidative Medicine …, 2021 - Wiley Online Library
Appropriate mitochondrial physiology is an essential for health and survival. Cells have
developed unique mechanisms to adapt to stress circumstances and changes in metabolic …

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

MS Bonkowski, DA Sinclair - Nature reviews Molecular cell biology, 2016 - nature.com
Abstract The sirtuins (SIRT1–7) are a family of nicotinamide adenine dinucleotide (NAD+)-
dependent deacylases with remarkable abilities to prevent diseases and even reverse …

Collapse of the world's largest herbivores

WJ Ripple, TM Newsome, C Wolf, R Dirzo… - Science …, 2015 - science.org
Large wild herbivores are crucial to ecosystems and human societies. We highlight the 74
largest terrestrial herbivore species on Earth (body mass≥ 100 kg), the threats they face …

Properties of Resveratrol: In Vitro and In Vivo Studies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans

J Gambini, M Inglés, G Olaso… - Oxidative medicine …, 2015 - Wiley Online Library
Plants containing resveratrol have been used effectively in traditional medicine for over
2000 years. It can be found in some plants, fruits, and derivatives, such as red wine …

Mitochondria and reactive oxygen species in aging and age-related diseases

C Giorgi, S Marchi, ICM Simoes, Z Ren… - International review of …, 2018 - Elsevier
Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …

[HTML][HTML] SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

NL Price, AP Gomes, AJY Ling, FV Duarte… - Cell metabolism, 2012 - cell.com
Resveratrol induces mitochondrial biogenesis and protects against metabolic decline, but
whether SIRT1 mediates these benefits is the subject of debate. To circumvent the …

Mitohormesis: promoting health and lifespan by increased levels of reactive oxygen species (ROS)

M Ristow, K Schmeisser - Dose-response, 2014 - journals.sagepub.com
Increasing evidence indicates that reactive oxygen species (ROS), consisting of superoxide,
hydrogen peroxide, and multiple others, do not only cause oxidative stress, but rather may …

Therapeutic potential of resveratrol: the in vivo evidence

JA Baur, DA Sinclair - Nature reviews Drug discovery, 2006 - nature.com
Resveratrol, a constituent of red wine, has long been suspected to have cardioprotective
effects. Interest in this compound has been renewed in recent years, first from its …

[HTML][HTML] Resveratrol: French paradox revisited

B Catalgol, S Batirel, Y Taga, NK Ozer - Frontiers in pharmacology, 2012 - frontiersin.org
Resveratrol is a polyphenol that plays a potentially important role in many disorders and has
been studied in different diseases. The research on this chemical started through the …