Interrupted time series (ITS) analysis is arguably the strongest quasi-experimental research
design. ITS is particularly useful when a randomized trial is infeasible or unethical. The …

OBJECTIVE: Large health care utilization databases are frequently used in variety of
settings to study the use and outcomes of therapeutics. Their size allows the study of …

Interrupted time series design is the strongest, quasi‐experimental approach for evaluating
longitudinal effects of interventions. Segmented regression analysis is a powerful statistical …

Medical practice in the United States has changed dramatically in the last several decades,
especially with more frequent use of prescription drugs. A higher volume and better-quality …

ContextPrescription drugs are instrumental to managing and preventing chronic disease.
Recent changes in US prescription drug cost sharing could affect access to them …

ContextHigher rates of microvascular complications have been reported for minorities.
Disparate access to quality health care is a common explanation for ethnic disparities in …

Patient adherence to treatment in chronic obstructive pulmonary disease (COPD) is
essential to optimise disease management. As with other chronic diseases, poor adherence …

ContextRising costs of medications and inequities in access have sparked calls for drug
policy reform in the United States and Canada. Control of drug expenditures by prescription …

What causes physicians to change the way they practice? This question is especially
important today because physicians' decisions influence not only the health of their patients …

Discusses categories of suboptimal prescribing of medications and the modification of such
practices in older patients. Definitions of polypharmacy, inappropriate prescribing and …