Urinary bladder cancer is a common malignancy, being characterized by substantial patient
mortality and management cost. Its high somatic-mutation frequency and molecular …

It is well established that cancer cells exhibit alterations in chromatin structure and
accessibility. Indeed, the dysregulation of many protein-coding players with enzymatic …

Background and purpose Histone deacetylase (HDAC) inhibitors (HDIs) can modulate the
epithelial-mesenchymal transition (EMT) progression and inhibit the migration and invasion …

Histone deacetylases (HDACs) influence diverse cellular processes and may contribute to
tumor development and progression by multiple mechanisms. Class I HDACs are often …

Background Oesophageal cancer remains a challenging disease with high mortality rates
and few therapeutic options. In view of these difficulties, epigenetic drugs have emerged as …

Background Despite adequate treatment and follow-up, around one fifth of patients with
localized bladder cancer will present with disease progression. Adequate prognostic …

BACKGROUND: Chromatin modifying enzymes, mainly through post translational
modifications, regulate chromatin architecture and by extension the underlying …

The aim of the present study was to identify and test a urine marker panel of genes involved
in DNA methylation and histone modification for the detection of urothelial carcinoma of the …

Objectives: To investigate the relationship of Silent mating type information regulation 2
homolog-1 (SIRT1) immunostaining to urothelial carcinoma of the urinary bladder (UCB) …

Epigenetic modifications are the principal mechanisms that influence chromatin
conformation. Histone methylation occurs on lysine and arginine residues. Lysine can be …