This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

G protein–coupled receptors (GPCRs) contribute to the regulation of every aspect of human
physiology and are therapeutic targets for the treatment of numerous diseases. As a …

The correct targeting, localization, regulation and signaling of metabotropic glutamate
receptors (mGluRs) represent major mechanisms underlying the complex function of …

Emerging evidence suggests that the transient receptor potential vanilloid type 1 channel
(TRPV1) is a novel target for the treatment of drug addiction, such as cocaine and morphine …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels (h channels) form the
molecular basis for the hyperpolarization-activated current, Ih, and modulation of h channels …

Opiate drugs mediate their analgesic, euphoriant, and rewarding effects by activating opioid
receptors. Pharmacological and molecular studies have demonstrated the existence of three …

Conditioned place preference and locomotor sensitization are rodent behavioral models
commonly used to investigate the actions of drugs of abuse. However, few studies have …

Significant interindividual differences in opioid sensitivity can hamper effective pain
treatment and increase the risk for substance abuse. Elucidation of the genetic mechanisms …

Opioid receptors, MORP, DORP and KORP, belong to the family A of G protein coupled
receptors (GPCR), and have been found to modulate a large number of physiological …

In the central nervous system, synaptic signal transduction depends on the regulation of
neurotransmitter receptors by interacting proteins. Here, we searched for proteins interacting …