Simple model systems reveal conserved mechanisms of Alzheimer's disease and related tauopathies

Y Jiang, LT MacNeil - Molecular Neurodegeneration, 2023 - Springer
The lack of effective therapies that slow the progression of Alzheimer's disease (AD) and
related tauopathies highlights the need for a more comprehensive understanding of the …

Protein homeostasis networks and the use of yeast to guide interventions in Alzheimer's disease

S Dhakal, I Macreadie - International Journal of Molecular Sciences, 2020 - mdpi.com
Alzheimer's Disease (AD) is a progressive multifactorial age-related neurodegenerative
disorder that causes the majority of deaths due to dementia in the elderly. Although various …

Global rewiring of cellular metabolism renders Saccharomyces cerevisiae Crabtree negative

Z Dai, M Huang, Y Chen, V Siewers… - Nature communications, 2018 - nature.com
Saccharomyces cerevisiae is a Crabtree-positive eukaryal model organism. It is believed
that the Crabtree effect has evolved as a competition mechanism by allowing for rapid …

[HTML][HTML] Calcium dysregulation in Alzheimer's disease: a target for new drug development

Y Wang, Y Shi, H Wei - Journal of Alzheimer's disease & …, 2017 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a devastating neurodegenerative disorder and the most
common cause of dementia among aged people whose population is rapidly increasing. AD …

FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism

X Chen, B Ji, X Hao, X Li, F Eisele, T Nyström… - Nature …, 2020 - nature.com
Alzheimer's disease (AD) is defined by progressive neurodegeneration, with oligomerization
and aggregation of amyloid-β peptides (Aβ) playing a pivotal role in its pathogenesis. In …

Gut microbiota influences Alzheimer's disease pathogenesis by regulating acetate in Drosophila model

Y Kong, B Jiang, X Luo - Future microbiology, 2018 - Taylor & Francis
Aim: The aim of present study is to investigate the relationship between gut microbiota and
Alzheimer's disease (AD) using Drosophila model. Materials & methods: The microbiota was …

Microbial Pathogenesis and Pathophysiology of Alzheimer's Disease: A Systematic Assessment of Microorganisms' Implications in the Neurodegenerative Disease

TC Ekundayo, TA Olasehinde, K Okaiyeto… - Frontiers in …, 2021 - frontiersin.org
Microbial infections have been linked to the pathogenesis and pathophysiology of
Alzheimer's disease (AD) and other neurodegenerative diseases. The present study aimed …

A toxic synergy between aluminium and amyloid beta in yeast

JB Mcdonald, S Dhakal, I Macreadie - International Journal of Molecular …, 2021 - mdpi.com
Alzheimer's disease (AD), the most prevalent, age-related, neurodegenerative disease, is
associated with the accumulation of amyloid beta (Aβ) and oxidative stress. However, the …

Recent insights on Alzheimer's disease originating from yeast models

D Seynnaeve, MD Vecchio, G Fruhmann… - International journal of …, 2018 - mdpi.com
In this review article, yeast model-based research advances regarding the role of Amyloid-β
(Aβ), Tau and frameshift Ubiquitin UBB+ 1 in Alzheimer's disease (AD) are discussed …

Protective effects of tanshinone IIA on SH-SY5Y cells against oAβ1–42-induced apoptosis due to prevention of endoplasmic reticulum stress

W Yang, J Zhang, L Shi, S Ji, X Yang, W Zhai… - … International Journal of …, 2019 - Elsevier
Endoplasmic reticulum (ER) stress caused by β-amyloid protein (Aβ) may play an important
role in the pathogenesis of Alzheimer disease (AD). Our previous data have indicated that …