Simple model systems reveal conserved mechanisms of Alzheimer's disease and related tauopathies
Y Jiang, LT MacNeil - Molecular Neurodegeneration, 2023 - Springer
The lack of effective therapies that slow the progression of Alzheimer's disease (AD) and
related tauopathies highlights the need for a more comprehensive understanding of the …
related tauopathies highlights the need for a more comprehensive understanding of the …
Protein homeostasis networks and the use of yeast to guide interventions in Alzheimer's disease
S Dhakal, I Macreadie - International Journal of Molecular Sciences, 2020 - mdpi.com
Alzheimer's Disease (AD) is a progressive multifactorial age-related neurodegenerative
disorder that causes the majority of deaths due to dementia in the elderly. Although various …
disorder that causes the majority of deaths due to dementia in the elderly. Although various …
Global rewiring of cellular metabolism renders Saccharomyces cerevisiae Crabtree negative
Saccharomyces cerevisiae is a Crabtree-positive eukaryal model organism. It is believed
that the Crabtree effect has evolved as a competition mechanism by allowing for rapid …
that the Crabtree effect has evolved as a competition mechanism by allowing for rapid …
[HTML][HTML] Calcium dysregulation in Alzheimer's disease: a target for new drug development
Y Wang, Y Shi, H Wei - Journal of Alzheimer's disease & …, 2017 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a devastating neurodegenerative disorder and the most
common cause of dementia among aged people whose population is rapidly increasing. AD …
common cause of dementia among aged people whose population is rapidly increasing. AD …
FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism
Alzheimer's disease (AD) is defined by progressive neurodegeneration, with oligomerization
and aggregation of amyloid-β peptides (Aβ) playing a pivotal role in its pathogenesis. In …
and aggregation of amyloid-β peptides (Aβ) playing a pivotal role in its pathogenesis. In …
Gut microbiota influences Alzheimer's disease pathogenesis by regulating acetate in Drosophila model
Y Kong, B Jiang, X Luo - Future microbiology, 2018 - Taylor & Francis
Aim: The aim of present study is to investigate the relationship between gut microbiota and
Alzheimer's disease (AD) using Drosophila model. Materials & methods: The microbiota was …
Alzheimer's disease (AD) using Drosophila model. Materials & methods: The microbiota was …
Microbial Pathogenesis and Pathophysiology of Alzheimer's Disease: A Systematic Assessment of Microorganisms' Implications in the Neurodegenerative Disease
Microbial infections have been linked to the pathogenesis and pathophysiology of
Alzheimer's disease (AD) and other neurodegenerative diseases. The present study aimed …
Alzheimer's disease (AD) and other neurodegenerative diseases. The present study aimed …
A toxic synergy between aluminium and amyloid beta in yeast
Alzheimer's disease (AD), the most prevalent, age-related, neurodegenerative disease, is
associated with the accumulation of amyloid beta (Aβ) and oxidative stress. However, the …
associated with the accumulation of amyloid beta (Aβ) and oxidative stress. However, the …
Recent insights on Alzheimer's disease originating from yeast models
D Seynnaeve, MD Vecchio, G Fruhmann… - International journal of …, 2018 - mdpi.com
In this review article, yeast model-based research advances regarding the role of Amyloid-β
(Aβ), Tau and frameshift Ubiquitin UBB+ 1 in Alzheimer's disease (AD) are discussed …
(Aβ), Tau and frameshift Ubiquitin UBB+ 1 in Alzheimer's disease (AD) are discussed …
Protective effects of tanshinone IIA on SH-SY5Y cells against oAβ1–42-induced apoptosis due to prevention of endoplasmic reticulum stress
W Yang, J Zhang, L Shi, S Ji, X Yang, W Zhai… - … International Journal of …, 2019 - Elsevier
Endoplasmic reticulum (ER) stress caused by β-amyloid protein (Aβ) may play an important
role in the pathogenesis of Alzheimer disease (AD). Our previous data have indicated that …
role in the pathogenesis of Alzheimer disease (AD). Our previous data have indicated that …