Creation and application of virtual patient cohorts of heart models

SA Niederer, Y Aboelkassem… - … of the Royal …, 2020 - royalsocietypublishing.org
Patient-specific cardiac models are now being used to guide therapies. The increased use
of patient-specific cardiac simulations in clinical care will give rise to the development of …

The openCARP simulation environment for cardiac electrophysiology

G Plank, A Loewe, A Neic, C Augustin… - Computer methods and …, 2021 - Elsevier
Abstract Background and Objective: Cardiac electrophysiology is a medical specialty with a
long and rich tradition of computational modeling. Nevertheless, no community standard for …

Using cardiac ionic cell models to interpret clinical data

C Corrado, A Avezzù, AWC Lee… - WIREs Mechanisms …, 2021 - Wiley Online Library
For over 100 years cardiac electrophysiology has been measured in the clinic. The electrical
signals that can be measured span from noninvasive ECG and body surface potentials …

Effect of scar and His–Purkinje and myocardium conduction on response to conduction system pacing

M Strocchi, K Gillette, A Neic, MK Elliott… - Journal of …, 2023 - Wiley Online Library
Introduction Conduction system pacing (CSP), in the form of His bundle pacing (HBP) or left
bundle branch pacing (LBBP), is emerging as a valuable cardiac resynchronization therapy …

Credibility assessment of patient-specific computational modeling using patient-specific cardiac modeling as an exemplar

S Galappaththige, RA Gray, CM Costa… - PLoS computational …, 2022 - journals.plos.org
Reliable and robust simulation of individual patients using patient-specific models (PSMs) is
one of the next frontiers for modeling and simulation (M&S) in healthcare. PSMs, which form …

A matrix–free high–order solver for the numerical solution of cardiac electrophysiology

PC Africa, M Salvador, P Gervasio, L Dede… - Journal of …, 2023 - Elsevier
We propose a matrix–free solver for the numerical solution of the cardiac electrophysiology
model consisting of the monodomain nonlinear reaction–diffusion equation coupled with a …

Modelling the interaction between stem cells derived cardiomyocytes patches and host myocardium to aid non-arrhythmic engineered heart tissue design

D Fassina, CM Costa, S Longobardi… - PLoS computational …, 2022 - journals.plos.org
Application of epicardial patches constructed from human-induced pluripotent stem cell-
derived cardiomyocytes (hiPSC-CMs) has been proposed as a long-term therapy to treat …

The first 10 years of the international coordination network for standards in systems and synthetic biology (COMBINE)

D Waltemath, M Golebiewski, ML Blinov… - Journal of integrative …, 2020 - degruyter.com
This paper presents a report on outcomes of the 10th Computational Modeling in Biology
Network (COMBINE) meeting that was held in Heidelberg, Germany, in July of 2019. The …

Leadless left bundle branch area pacing in cardiac resynchronisation therapy: advances, challenges and future directions

N Wijesuriya, MK Elliott, V Mehta, BS Sidhu… - Frontiers in …, 2022 - frontiersin.org
Leadless left bundle branch area pacing (LBBAP) represents the merger of two rapidly
progressing areas in the field of cardiac resynchronisation therapy (CRT). It combines the …

[HTML][HTML] Direct comparison of a novel antitachycardia pacing algorithm against present methods using virtual patient modeling

DJ Swenson, RT Taepke, JJE Blauer, E Kwan… - Heart Rhythm, 2020 - Elsevier
Background Antitachycardia pacing (ATP) success rates as low as 50% for fast ventricular
tachycardias (VTs) have been reported providing an opportunity for improved ATP to …