Protein nanocages have been explored as potential carriers in biomedicine. Formed by the
self-assembly of protein subunits, the caged structure has three surfaces that can be …

Highlights•Caged proteins can overcome limitations of other nanoparticles for drug
delivery.•Unique physical, chemical, and recombinant methods allow drug loading/release.• …

The ability to chemically control protein-protein interactions would allow the interrogation of
dynamic cellular processes and lead to a better understanding and exploitation of self …

In recent years, the practical application of protein-based nanoparticles (PNPs) has
expanded rapidly into areas like drug delivery, vaccine development, and biocatalysis …

Many current cancer vaccine strategies suffer from the inability to mount a CD8 T cell
response that is strong enough to overcome the low immunogenicity of tumors. Viruses …

Infectious diseases are a major threat to global human health, yet prophylactic treatment
options can be limited, as safe and efficacious vaccines exist only for a fraction of all …

Chemically and/or genetically engineered viruses, viral capsids and viral-like particles carry
the promise of important and diverse applications in biomedicine, biotechnology and …

Protein cages (viral and non-viral) found in nature have evolved for a variety of purposes
and are found in all kingdoms of life. The main functions of these nanoscale compartments …

The E2 component of pyruvate dehydrogenase is engineered to form a caged, hollow
dodecahedral protein assembly, and the feasibility of this scaffold to be used as a drug …

Virus-like particles (VLPs) are nanoscale biological structures consisting of viral proteins
assembled in a morphology that mimic the native virion but do not contain the viral genetic …