Cell type-specific transcriptional differences between brain tissues from donors with
Alzheimer's disease (AD) and unaffected controls have been well documented, but few …

Eukaryotic gene regulation is a combinatorial, dynamic, and quantitative process that plays
a vital role in development and disease and can be modeled at a systems level in gene …

Stress-responsive genes are lowly transcribed under normal conditions and robustly
induced in response to stress. The significant difference between basal and induced …

Early-life stress and ovarian hormones contribute to increased female vulnerability to
cocaine addiction. Here, we reveal molecular substrates in the reward area, the nucleus …

Some fungal accessory chromosomes (ACs) may contribute to virulence in plants. However,
the mechanisms by which ACs determine specific traits associated with lifestyle transitions …

Abstract Aflatoxin B 1 (AFB 1) not only causes significant losses in livestock production but
also poses a serious threat to human health. It is the most carcinogenic among known …

Background: Prostate cancer, a common malignancy, is driven by androgen receptor (AR)
signaling. Understanding the function of AR signaling is critical for prostate cancer research …

Introduction European local ancestry (ELA) surrounding apolipoprotein E (APOE) ε4 confers
higher risk for Alzheimer's disease (AD) compared to African local ancestry (ALA). We …

The hallmark characteristic of macrophages lies in their inherent plasticity, allowing them to
adapt to dynamic microenvironments. Leishmania strategically modulates the phenotypic …

Background European local ancestry (ELA) surrounding APOE4 is associated with a higher
risk for Alzheimer Disease (AD) compared to African local ancestry (ALA). We previously …