Cells are equipped with numerous sensors that recognize nucleic acids, which probably
evolved for defence against viruses. Once triggered, these sensors stimulate the production …

Patients with systemic lupus erythematosus (SLE) frequently show symptoms of central
nervous system (CNS) involvement, termed neuropsychiatric SLE (NPSLE). The CNS …

Background Type I interferons are involved in systemic lupus erythematosus (SLE)
pathogenesis. In a phase 2 trial, anifrolumab, a human monoclonal antibody to type I …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple
organs. A complex interaction of genetics, environment, and hormones leads to immune …

Long noncoding RNAs (lncRNAs) have recently been identified to be tightly linked to diverse
human diseases. However, our knowledge of Systemic Lupus Erythematosus (SLE)-related …

Initially used as antimalarial drugs, hydroxychloroquine (HCQ) and, to a lesser extent,
chloroquine (CQ) are currently being used to treat several diseases. Due to its cost …

Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the
loss of tolerance to nuclear self antigens, the production of pathogenic autoantibodies and …

Objective Dysregulation of innate and adaptive immune responses contributes to the
pathogenesis of systemic lupus erythematosus (SLE) and its associated premature vascular …

Objectives Previous studies have reported that a few inflammatory cytokines have
associations with systemic lupus erythematosus (SLE)—for example, IL-6, IL-17, and …

Overactivity of the germinal center (GC) pathway resulting from accumulation of follicular
helper T (Tfh) cells causes autoimmunity, underscoring the need to understand the factors …