The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation
and trafficking of inflammatory mediators as well as tumor progression and metastasis. The …

During acute infectious and inflammatory conditions, a large number of neutrophils are in
high demand as they are consumed in peripheral organs. The hematopoietic system rapidly …

The young circulatory milieu capable of delaying aging in individual tissues is of interest as
rejuvenation strategies, but how it achieves cellular-and systemic-level effects has remained …

Hematopoietic stem cells (HSC) are responsible for the production of mature blood cells. To
ensure that the HSC pool does not get exhausted over the lifetime of an individual, most …

Central B cell tolerance is believed to be regulated by B cell receptor signaling induced by
the recognition of self-antigens in immature B cells. Using humanized mice with defective …

This review describes the role of CXCL1, a chemokine crucial in inflammation as a
chemoattractant for neutrophils, in physiology and in selected major non-cancer diseases …

Recruitment of myeloid-derived suppressor cells (MDSC) into the tumor microenvironment
(TME) contributes to cancer immune evasion. MDSCs express the chemokine receptor …

Hematopoietic stem cells (HSCs) are primarily dormant in a cell-cycle quiescence state to
preserve their self-renewal capacity and long-term maintenance, which is essential for the …

Accumulation of myeloid‐derived suppressor cells (MDSC) in tumor‐bearing hosts is a
hallmark of tumor‐associated inflammation, which is thought to be a barrier to …

Myeloid-derived suppressor cells (MDSCs) comprise a critical component of the tumor
environment and CXCR2 reportedly plays a key role in the pathophysiology of various …