Growth and neurodevelopment of HIV-exposed uninfected children: a conceptual framework

CJ Wedderburn, C Evans, S Yeung, DM Gibb… - Current HIV/AIDS …, 2019 - Springer
Abstract Purpose of Review The population of HIV-exposed uninfected (HEU) children is
expanding rapidly, and over one million HEU infants are born each year globally. Several …

Evaluating neurodevelopmental consequences of perinatal exposure to antiretroviral drugs: current challenges and new approaches

JG Schnoll, B Temsamrit, D Zhang, H Song… - Journal of Neuroimmune …, 2021 - Springer
As antiretroviral therapy (ART) becomes increasingly affordable and accessible to women of
childbearing age across the globe, the number of children who are exposed to Human …

Neurodevelopment of breastfed HIV-exposed uninfected and HIV-unexposed children in South Africa

SM le Roux, KA Donald, K Brittain, TK Phillips, A Zerbe… - Aids, 2018 - journals.lww.com
Objectives: To assess neurodevelopment of breastfed HIV-exposed uninfected (HEU) and
breastfed HIV-unexposed children in the context of universal maternal antiretroviral therapy …

Early structural brain development in infants exposed to HIV and antiretroviral therapy in utero in a South African birth cohort

CJ Wedderburn, NA Groenewold, A Roos… - African Journal of …, 2022 - journals.lww.com
Introduction: There is a growing population of children who are HIV-exposed and uninfected
(HEU) with the successful expansion of antiretroviral therapy (ART) use in pregnancy …

Early child development in children who are HIV‐exposed uninfected compared to children who are HIV‐unexposed: observational sub‐study of a cluster‐randomized …

R Ntozini, J Chandna, C Evans… - Journal of the …, 2020 - Wiley Online Library
Introduction Exposure to maternal HIV may affect early child development (ECD), although
previous studies have reported heterogeneous findings. We evaluated ECD among children …

Long-term alterations in brain and behavior after postnatal Zika virus infection in infant macaques

J Raper, Z Kovacs-Balint, M Mavigner… - Nature …, 2020 - nature.com
Zika virus (ZIKV) infection has a profound impact on the fetal nervous system. The postnatal
period is also a time of rapid brain growth, and it is important to understand the potential …

Maternal ART throughout gestation prevents caudate volume reductions in neonates who are HIV exposed but uninfected

A Ibrahim, FL Warton, S Fry, MF Cotton… - Frontiers in …, 2023 - frontiersin.org
Introduction Successful programmes for prevention of vertical HIV transmission have
reduced the risk of infant HIV infection in South Africa from 8% in 2008 to below 1% in …

A neurometabolic pattern of elevated myo-inositol in children who are HIV-exposed and uninfected: A South African birth cohort study

C Bertran-Cobo, CJ Wedderburn… - Frontiers in …, 2022 - frontiersin.org
Introduction Exposure to maternal HIV in pregnancy may be a risk factor for impaired child
neurodevelopment during the first years of life. Altered neurometabolites have been …

Neuroanatomical changes underlying vertical HIV infection in adolescents

X Yu, L Gao, H Wang, Z Yin, J Fang, J Chen… - Frontiers in …, 2019 - frontiersin.org
Purpose: The aim of this study was to investigate how human immunodeficiency virus (HIV)
affects brain development in adolescents, what are susceptible brain regions, and how …

In utero exposure to HIV and/or antiretroviral therapy: a systematic review of preclinical and clinical evidence of cognitive outcomes

MS McHenry, KA Balogun… - Journal of the …, 2019 - Wiley Online Library
Introduction With the increasing number of children exposed to HIV or antiretroviral therapy
in utero, there are concerns that this population may have worse neurodevelopmental …