The role of minerals in the optimal functioning of the immune system

C Weyh, K Krüger, P Peeling, L Castell - Nutrients, 2022 - mdpi.com
Minerals fulfil a wide variety of functions in the optimal functioning of the immune system.
This review reports on the minerals that are essential for the immune system's function and …

[HTML][HTML] Magnesium in aging, health and diseases

M Barbagallo, N Veronese, LJ Dominguez - Nutrients, 2021 - mdpi.com
Several changes of magnesium (Mg) metabolism have been reported with aging, including
diminished Mg intake, impaired intestinal Mg absorption and renal Mg wasting. Mild Mg …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2019 - Wiley Online Library
These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

Calcium signalling in T cells

M Trebak, JP Kinet - Nature Reviews Immunology, 2019 - nature.com
Abstract Calcium (Ca2+) signalling is of paramount importance to immunity. Regulated
increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex …

Regulation of the germinal center response

M Stebegg, SD Kumar, A Silva-Cayetano… - Frontiers in …, 2018 - frontiersin.org
The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid
tissues, producing long-lived antibody secreting plasma cells and memory B cells, which …

Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats

Y Zhang, J Xu, YC Ruan, MK Yu, M O'Laughlin… - Nature medicine, 2016 - nature.com
Orthopedic implants containing biodegradable magnesium have been used for fracture
repair with considerable efficacy; however, the underlying mechanisms by which these …

Phosphoenolpyruvate is a metabolic checkpoint of anti-tumor T cell responses

PC Ho, JD Bihuniak, AN Macintyre, M Staron, X Liu… - Cell, 2015 - cell.com
Activated T cells engage aerobic glycolysis and anabolic metabolism for growth,
proliferation, and effector functions. We propose that a glucose-poor tumor …

[HTML][HTML] Magnesium in man: implications for health and disease

JHF De Baaij, JGJ Hoenderop… - Physiological …, 2015 - journals.physiology.org
Abstract Magnesium (Mg 2+) is an essential ion to the human body, playing an instrumental
role in supporting and sustaining health and life. As the second most abundant intracellular …

The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum

S Srikanth, JS Woo, B Wu, YM El-Sherbiny… - Nature …, 2019 - nature.com
Stimulator of interferon genes (STING) is an endoplasmic reticulum (ER) signaling adaptor
that is essential for the type I interferon response to DNA pathogens. Aberrant activation of …

NLRP3 inflammasome in neurological diseases, from functions to therapies

L Song, L Pei, S Yao, Y Wu, Y Shang - Frontiers in cellular …, 2017 - frontiersin.org
Neuroinflammation has been identified as a causative factor of multiple neurological
diseases. The nucleotide-binding oligomerization domain-, leucine-rich repeat-and pyrin …