Stem cell therapy for spinal cord injury

L Huang, C Fu, F Xiong, C He, Q Wei - Cell transplantation, 2021 - journals.sagepub.com
Traumatic spinal cord injury (SCI) results in direct and indirect damage to neural tissues,
which results in motor and sensory dysfunction, dystonia, and pathological reflex that …

Myelin damage and repair in pathologic CNS: challenges and prospects

A Alizadeh, SM Dyck… - Frontiers in molecular …, 2015 - frontiersin.org
Injury to the central nervous system (CNS) results in oligodendrocyte cell death and
progressive demyelination. Demyelinated axons undergo considerable physiological …

A review of functional electrical stimulation treatment in spinal cord injury

S Luo, H Xu, Y Zuo, X Liu, AH All - Neuromolecular medicine, 2020 - Springer
Functional electrical stimulation (FES) has been widely adopted to elicit muscle contraction
in rehabilitation training after spinal cord injury (SCI). Conventional FES modalities include …

Human pluripotent stem cells-based therapies for neurodegenerative diseases: current status and challenges

E Ford, J Pearlman, T Ruan, J Manion, M Waller… - Cells, 2020 - mdpi.com
Neurodegenerative diseases are characterized by irreversible cell damage, loss of neuronal
cells and limited regeneration potential of the adult nervous system. Pluripotent stem cells …

The role of current techniques and concepts in peripheral nerve repair

KS Houschyar, A Momeni, MN Pyles… - Plastic surgery …, 2016 - Wiley Online Library
Patients with peripheral nerve injuries, especially severe injury, often face poor nerve
regeneration and incomplete functional recovery, even after surgical nerve repair. This …

Oligodendrocyte precursor cells in spinal cord injury: a review and update

N Li, GKK Leung - BioMed research international, 2015 - Wiley Online Library
Spinal cord injury (SCI) is a devastating condition to individuals, families, and society.
Oligodendrocyte loss and demyelination contribute as major pathological processes of …

Biomimetic hydrogels direct spinal progenitor cell differentiation and promote functional recovery after spinal cord injury

SA Geissler, AL Sabin, RR Besser… - Journal of neural …, 2018 - iopscience.iop.org
Objective. Demyelination that results from disease or traumatic injury, such as spinal cord
injury (SCI), can have a devastating effect on neural function and recovery. Many …

Cell reprogramming for oligodendrocytes: A review of protocols and their applications to disease modeling and cell‐based remyelination therapies

A McCaughey‐Chapman… - Journal of Neuroscience …, 2023 - Wiley Online Library
Oligodendrocytes are a type of glial cells that produce a lipid‐rich membrane called myelin.
Myelin assembles into a sheath and lines neuronal axons in the brain and spinal cord to …

Repeated injections of human umbilical cord blood-derived mesenchymal stem cells significantly promotes functional recovery in rabbits with spinal cord injury of two …

C Yang, G Wang, F Ma, B Yu, F Chen, J Yang… - Stem cell research & …, 2018 - Springer
Abstract Background Spinal cord injuries (SCIs) are sustained by an increasing number of
patients each year worldwide. The treatment of SCIs has long been a hard nut to crack for …

Early intervention for spinal cord injury with human induced pluripotent stem cells oligodendrocyte progenitors

AH All, P Gharibani, S Gupta, FA Bazley, N Pashai… - PLoS …, 2015 - journals.plos.org
Induced pluripotent stem (iPS) cells are at the forefront of research in regenerative medicine
and are envisaged as a source for personalized tissue repair and cell replacement therapy …