Adaptive immune responses mediated by T cells and B cells are crucial for protective
immunity against pathogens and tumors. Differentiation and function of immune cells require …

With the burgeoning use of immune-based treatments for cancer, never has there been a
greater need to understand the tumour microenvironment within which immune cells …

Cancer cells characteristically consume glucose through Warburg metabolism, a process
that forms the basis of tumour imaging by positron emission tomography (PET). Tumour …

Nicotinamide N-methyltransferase (NNMT) is an intracellular methyltransferase, catalyzing
the N-methylation of nicotinamide (NAM) to form 1-methylnicotinamide (1-MNAM), in which …

Tumor cell phenotypes and anti-tumor immune responses are shaped by local metabolite
availability, but intratumoral metabolite heterogeneity (IMH) and its phenotypic …

Poly (ADP) ribosylation inhibitors (PARPis) are toxic to cancer cells with homologous
recombination (HR) deficiency but not to HR-proficient cells in the tumor microenvironment …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

Dissolution dynamic nuclear polarization (dDNP) increases the sensitivity of magnetic
resonance imaging by more than 10,000 times, enabling in vivo metabolic imaging to be …

Tumour metabolism is controlled by coordinated changes in metabolite abundance and
gene expression, but simultaneous quantification of metabolites and transcripts in primary …

Nicotinamide N-methyltransferase (NNMT) methylates nicotinamide (NA) to generate 1-
methyl nicotinamide. Since its discovery 70 years ago, the appreciation of the role of NNMT …