Proteogenomic network analysis reveals dysregulated mechanisms and potential mediators in Parkinson's disease
A Doostparast Torshizi, DT Truong, L Hou… - Nature …, 2024 - nature.com
Parkinson's disease is highly heterogeneous across disease symptoms, clinical
manifestations and progression trajectories, hampering the identification of therapeutic …
manifestations and progression trajectories, hampering the identification of therapeutic …
Coexistence of amyotrophic lateral sclerosis and Alzheimer's disease: Case report and review of the literature
We describe a case of amyotrophic lateral sclerosis (ALS) associated with Alzheimer's
disease (AD) and review the literature about the coexistence of the two entities, highlighting …
disease (AD) and review the literature about the coexistence of the two entities, highlighting …
Exploring the Regulatory Landscape of Dementia: Insights from Non-Coding RNAs
J Kim, WR Kim, EG Park, DH Lee, YJ Lee… - International Journal of …, 2024 - mdpi.com
Dementia, a multifaceted neurological syndrome characterized by cognitive decline, poses
significant challenges to daily functioning. The main causes of dementia, including …
significant challenges to daily functioning. The main causes of dementia, including …
[HTML][HTML] The shared genetic risk architecture of neurological and psychiatric disorders: a genome-wide analysis
While neurological and psychiatric disorders have historically been considered to reflect
distinct pathogenic entities, recent findings suggest shared pathobiological mechanisms …
distinct pathogenic entities, recent findings suggest shared pathobiological mechanisms …
A multi-region single nucleus transcriptomic atlas of Parkinson's disease
Parkinson's Disease (PD) is a debilitating neurodegenerative disorder, characterized by
motor and cognitive impairments, that affects> 1% of the population over the age of 60. The …
motor and cognitive impairments, that affects> 1% of the population over the age of 60. The …
[HTML][HTML] Human Leukocyte Antigen Polymorphism and Blood Biomarker Profiles in Parkinson's Disease: A Pilot Study in a Latvian Cohort
O Minibajeva, G Karelis, M Zolovs, V Ķēniņa - Biomedicines, 2024 - mdpi.com
Background: Parkinson's disease (PD) is a neurodegenerative disorder characterised by a
high prevalence of sporadic cases. Various molecular mechanisms are involved in its …
high prevalence of sporadic cases. Various molecular mechanisms are involved in its …
Evaluating metabolome-wide causal effects on risk for psychiatric and neurodegenerative disorders
Evidence indicates phenotypic and biological overlap between psychiatric and
neurodegenerative disorders. Further identification of underlying mutual and unique …
neurodegenerative disorders. Further identification of underlying mutual and unique …
Interpretation of Neurodegenerative GWAS Risk Alleles in Microglia and their Interplay with Other Cell Types
Microglia have been implicated in numerous neurodegenerative and neuroinflammatory
disorders; however, the causal contribution of this immune cell type is frequently debated …
disorders; however, the causal contribution of this immune cell type is frequently debated …
Investigating the genetic relationship between depression symptoms and Alzheimer's Disease in clinically diagnosed and proxy cases
Depression is a risk factor for the later development of Alzheimer's disease (AD), but
evidence for their genetic relationship is mixed. Assessing depression symptom specific …
evidence for their genetic relationship is mixed. Assessing depression symptom specific …
PET and SPECT imaging as a solid guide to detect and discriminate atypical phenotypes of neurodegenerative disorders
Introduction and aim. Atypical or mixed presentations of neurodegenerative disorders may
postpone or confound the final diagnosis. Molecular imaging with positron emission …
postpone or confound the final diagnosis. Molecular imaging with positron emission …