Proteogenomic network analysis reveals dysregulated mechanisms and potential mediators in Parkinson's disease

A Doostparast Torshizi, DT Truong, L Hou… - Nature …, 2024 - nature.com
Parkinson's disease is highly heterogeneous across disease symptoms, clinical
manifestations and progression trajectories, hampering the identification of therapeutic …

Coexistence of amyotrophic lateral sclerosis and Alzheimer's disease: Case report and review of the literature

F Verde, EN Aiello, L Adobbati… - Journal of …, 2023 - journals.sagepub.com
We describe a case of amyotrophic lateral sclerosis (ALS) associated with Alzheimer's
disease (AD) and review the literature about the coexistence of the two entities, highlighting …

Exploring the Regulatory Landscape of Dementia: Insights from Non-Coding RNAs

J Kim, WR Kim, EG Park, DH Lee, YJ Lee… - International Journal of …, 2024 - mdpi.com
Dementia, a multifaceted neurological syndrome characterized by cognitive decline, poses
significant challenges to daily functioning. The main causes of dementia, including …

[HTML][HTML] The shared genetic risk architecture of neurological and psychiatric disorders: a genome-wide analysis

OB Smeland, G Kutrolli, S Bahrami, V Fominykh… - medRxiv, 2023 - ncbi.nlm.nih.gov
While neurological and psychiatric disorders have historically been considered to reflect
distinct pathogenic entities, recent findings suggest shared pathobiological mechanisms …

A multi-region single nucleus transcriptomic atlas of Parkinson's disease

P NM, JF Fullard, T Clarence, D Mathur, C Casey… - Scientific data, 2024 - nature.com
Parkinson's Disease (PD) is a debilitating neurodegenerative disorder, characterized by
motor and cognitive impairments, that affects> 1% of the population over the age of 60. The …

[HTML][HTML] Human Leukocyte Antigen Polymorphism and Blood Biomarker Profiles in Parkinson's Disease: A Pilot Study in a Latvian Cohort

O Minibajeva, G Karelis, M Zolovs, V Ķēniņa - Biomedicines, 2024 - mdpi.com
Background: Parkinson's disease (PD) is a neurodegenerative disorder characterised by a
high prevalence of sporadic cases. Various molecular mechanisms are involved in its …

Evaluating metabolome-wide causal effects on risk for psychiatric and neurodegenerative disorders

L Gilchrist, J Mutz, P Hysi, C Legido-Quigley, S Koks… - medRxiv, 2024 - medrxiv.org
Evidence indicates phenotypic and biological overlap between psychiatric and
neurodegenerative disorders. Further identification of underlying mutual and unique …

Interpretation of Neurodegenerative GWAS Risk Alleles in Microglia and their Interplay with Other Cell Types

IR Holtman, CK Glass, A Nott - Microglia: Physiology, Pathophysiology …, 2024 - Springer
Microglia have been implicated in numerous neurodegenerative and neuroinflammatory
disorders; however, the causal contribution of this immune cell type is frequently debated …

Investigating the genetic relationship between depression symptoms and Alzheimer's Disease in clinically diagnosed and proxy cases

L Gilchrist, TP Spargo, RE Green, JRI Coleman… - medRxiv, 2023 - medrxiv.org
Depression is a risk factor for the later development of Alzheimer's disease (AD), but
evidence for their genetic relationship is mixed. Assessing depression symptom specific …

PET and SPECT imaging as a solid guide to detect and discriminate atypical phenotypes of neurodegenerative disorders

L Ruffini, A Zilioli, V Cervati, F Lauretan, F Misirocchi… - 2024 - repozytorium.ur.edu.pl
Introduction and aim. Atypical or mixed presentations of neurodegenerative disorders may
postpone or confound the final diagnosis. Molecular imaging with positron emission …