Thoughtful clinical trial design is critical for efficient therapeutic development, particularly in
the field of amyotrophic lateral sclerosis (ALS), where trials often aim to detect modest …

Recent technological advances in respiratory support and monitoring have dramatically
enhanced the utility of long-term noninvasive ventilation (NIV). Improved quality of life and …

Background and aims Internet use has become an important part of daily living. However, for
a minority it may become problematic. Moreover, problematic use of the Internet/smartphone …

Automatic speech assessments have the potential to dramatically improve ALS clinical
practice and facilitate patient stratification for ALS clinical trials. Acoustic speech analysis …

Purpose: The increased use of telehealth practices has created a critical need for home-
based surrogate markers for prognostic respiratory indicators of disease progression in …

Objective Pulmonary dysfunction after stroke is increasingly gaining attention from clinical
and rehabilitation specialists. However, owing to cognitive and motor dysfunction in patients …

Amyotrophic lateral sclerosis (ALS) is a rare, neurodegenerative motor neuron disease that
affects voluntary muscle movement. Often, difficulty in coughing, breathing, and swallowing …

Abstract Introduction/Aims Evaluations of pulmonary, cough, and swallow function are
frequently performed to assess disease progression in amyotrophic lateral sclerosis (ALS) …

Objective: We endeavor to draw attention to what appears to be a gap in the management of
ALS patients and the potential uncertainty of clinical drug trial research results in the …

Respiratory failure assessment is among the most debatable research topics in amyotrophic
lateral sclerosis (ALS) clinical research due to the wide heterogeneity of its presentation …