[HTML][HTML] Considerations for amyotrophic lateral sclerosis (ALS) clinical trial design
CN Fournier - Neurotherapeutics, 2022 - Elsevier
Thoughtful clinical trial design is critical for efficient therapeutic development, particularly in
the field of amyotrophic lateral sclerosis (ALS), where trials often aim to detect modest …
the field of amyotrophic lateral sclerosis (ALS), where trials often aim to detect modest …
Practical guide to management of long-term noninvasive ventilation for adults with chronic neuromuscular disease
J Hansen-Flaschen, J Ackrivo - Respiratory Care, 2023 - rc.rcjournal.com
Recent technological advances in respiratory support and monitoring have dramatically
enhanced the utility of long-term noninvasive ventilation (NIV). Improved quality of life and …
enhanced the utility of long-term noninvasive ventilation (NIV). Improved quality of life and …
Temporal associations between physical activity and three types of problematic use of the internet: a six-month longitudinal study
Background and aims Internet use has become an important part of daily living. However, for
a minority it may become problematic. Moreover, problematic use of the Internet/smartphone …
a minority it may become problematic. Moreover, problematic use of the Internet/smartphone …
Detecting bulbar amyotrophic lateral sclerosis (ALS) using automatic acoustic analysis
Automatic speech assessments have the potential to dramatically improve ALS clinical
practice and facilitate patient stratification for ALS clinical trials. Acoustic speech analysis …
practice and facilitate patient stratification for ALS clinical trials. Acoustic speech analysis …
Maximum phonation time as a surrogate marker for airway clearance physiologic capacity and pulmonary function in individuals with amyotrophic lateral sclerosis
Purpose: The increased use of telehealth practices has created a critical need for home-
based surrogate markers for prognostic respiratory indicators of disease progression in …
based surrogate markers for prognostic respiratory indicators of disease progression in …
Diaphragmatic ultrasound can help evaluate pulmonary dysfunction in patients with stroke
Y Chen, S Zhou, L Liao, J He, D Tang, W Wu… - Frontiers in …, 2023 - frontiersin.org
Objective Pulmonary dysfunction after stroke is increasingly gaining attention from clinical
and rehabilitation specialists. However, owing to cognitive and motor dysfunction in patients …
and rehabilitation specialists. However, owing to cognitive and motor dysfunction in patients …
Airway clearance strategies and secretion management in amyotrophic lateral sclerosis
KL McHenry - Respiratory Care, 2024 - rc.rcjournal.com
Amyotrophic lateral sclerosis (ALS) is a rare, neurodegenerative motor neuron disease that
affects voluntary muscle movement. Often, difficulty in coughing, breathing, and swallowing …
affects voluntary muscle movement. Often, difficulty in coughing, breathing, and swallowing …
Relationship between pulmonary, cough, and swallowing functions in individuals with amyotrophic lateral sclerosis
Abstract Introduction/Aims Evaluations of pulmonary, cough, and swallow function are
frequently performed to assess disease progression in amyotrophic lateral sclerosis (ALS) …
frequently performed to assess disease progression in amyotrophic lateral sclerosis (ALS) …
Why is nutrition vital for advancing ALS care and clinical research?
EJ Kasarskis, R Tandan - Amyotrophic Lateral Sclerosis and …, 2023 - Taylor & Francis
Objective: We endeavor to draw attention to what appears to be a gap in the management of
ALS patients and the potential uncertainty of clinical drug trial research results in the …
ALS patients and the potential uncertainty of clinical drug trial research results in the …
Calculated Maximal Volume Ventilation (cMVV) as a Marker of Early Respiratory Failure in Amyotrophic Lateral Sclerosis (ALS)
Respiratory failure assessment is among the most debatable research topics in amyotrophic
lateral sclerosis (ALS) clinical research due to the wide heterogeneity of its presentation …
lateral sclerosis (ALS) clinical research due to the wide heterogeneity of its presentation …