The state of complement in COVID-19
Hyperactivation of the complement and coagulation systems is recognized as part of the
clinical syndrome of COVID-19. Here we review systemic complement activation and local …
clinical syndrome of COVID-19. Here we review systemic complement activation and local …
Immunity, endothelial injury and complement-induced coagulopathy in COVID-19
In December 2019, a novel coronavirus was isolated from the respiratory epithelium of
patients with unexplained pneumonia in Wuhan, China. This pathogen, named severe acute …
patients with unexplained pneumonia in Wuhan, China. This pathogen, named severe acute …
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
JC Holter, SE Pischke, E de Boer… - Proceedings of the …, 2020 - National Acad Sciences
Respiratory failure in the acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
pandemic is hypothesized to be driven by an overreacting innate immune response, where …
pandemic is hypothesized to be driven by an overreacting innate immune response, where …
Severe acute respiratory syndrome: historical, epidemiologic, and clinical features
Over the past 2 decades 2 previously unknown coronaviruses (CoVs), the severe acute
respiratory syndrome CoV (SARS-CoV) and the Middle East respiratory syndrome CoV …
respiratory syndrome CoV (SARS-CoV) and the Middle East respiratory syndrome CoV …
Highly pathogenic coronavirus N protein aggravates lung injury by MASP-2-mediated complement over-activation
T Gao, M Hu, X Zhang, H Li, L Zhu, H Liu, Q Dong… - MedRxiv, 2020 - medrxiv.org
An excessive immune response contributes to SARS-CoV, MERS-CoV and SARS-CoV-2
pathogenesis and lethality, but the mechanism remains unclear. In this study, the N proteins …
pathogenesis and lethality, but the mechanism remains unclear. In this study, the N proteins …
COVID-19 pandemic: Insights into structure, function, and hACE2 receptor recognition by SARS-CoV-2
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a newly emerging,
highly transmissible, and pathogenic coronavirus in humans that has caused global public …
highly transmissible, and pathogenic coronavirus in humans that has caused global public …
[HTML][HTML] The case of complement activation in COVID-19 multiorgan impact
The novel coronavirus disease COVID-19 originates in the lungs, but it may extend to other
organs, causing, in severe cases, multiorgan damage, including cardiac injury and acute …
organs, causing, in severe cases, multiorgan damage, including cardiac injury and acute …
Current pharmacological treatments for COVID‐19: What's next?
C Scavone, S Brusco, M Bertini… - British journal of …, 2020 - Wiley Online Library
Since December 2019 SARS‐Cov‐2 was found responsible for the disease COVID‐19,
which has spread worldwide. No specific therapies/vaccines are yet available for the …
which has spread worldwide. No specific therapies/vaccines are yet available for the …
The role of host genetics in the immune response to SARS‐CoV‐2 and COVID‐19 susceptibility and severity
IG Ovsyannikova, IH Haralambieva… - Immunological …, 2020 - Wiley Online Library
This article provides a review of studies evaluating the role of host (and viral) genetics
(including variation in HLA genes) in the immune response to coronaviruses, as well as the …
(including variation in HLA genes) in the immune response to coronaviruses, as well as the …
Complement activation contributes to severe acute respiratory syndrome coronavirus pathogenesis
Acute respiratory distress syndrome (ARDS) is immune-driven pathologies that are
observed in severe cases of severe acute respiratory syndrome coronavirus (SARS-CoV) …
observed in severe cases of severe acute respiratory syndrome coronavirus (SARS-CoV) …