Since the clinical approval of imatinib, the discovery of protein kinase downregulators
entered a prosperous age. However, challenges still exist in the discovery of kinase …

Identification of new antioxidant and anti-inflammatory bioactive molecules is an important
tool for selecting effective formulations for the treatment of inflammation. The mouse …

Modulation of inhibitor kappa B kinase-beta (IKK-β) kinase activity could be useful for
preventing inflammation that serves an efficient role in protection against cardiovascular …

The pivotal role of MRP3 protein in acute leukaemia and the efficacy of natural compounds
in cancer treatment have necessitated the current study to identify novel MRP3 inhibitors …

The Inhibitor of IKK-β (nuclear factor kappa B kinase subunit beta), a specific modulator of
NF-κB (nuclear factor-κB), is considered a valid target to discover new active compounds for …

Nonsense mutations in the CFTR gene prematurely terminate translation of the CFTR mRNA
leading to the production of a truncated protein that lacks normal function causing a more …

Inhibitor of nuclear factor kappa B kinase subunit beta (IKK-β), a specific regulator of nuclear
factor-κB (NF-κB), is considered a valid target to design novel candidate drugs to treat …

Ataluren, also known as PTC124, is a 5-(fluorophenyl)-1, 2, 4-oxadiazolyl-benzoic acid
suggested to suppress nonsense mutations by readthrough of premature stop codons in the …

Various inflammatory stimuli that activate the nuclear factor kappa B (NF-κB) signaling
pathway converge on a serine/threonine kinase that displays a key role in the activation of …

Cystic fibrosis (CF) patients develop a severe form of the disease when the cystic fibrosis
transmembrane conductance regulator (CFTR) gene is affected by nonsense mutations …