Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Nonalcoholic fatty liver disease (NAFLD) is one of the world's most common chronic liver
diseases. However, its pathogenesis remains unclear. With the deepening of research …

Diets rich in added sugars are associated with metabolic diseases, and studies have shown
a link between these pathologies and changes in the microbiome. Given the reported …

Over the past few decades, increasing prevalence of obesity caused an enormous medical,
social, and economic burden. As the sixth most important risk factor contributing to the …

Human thermogenic adipose tissue has long been touted as a promising therapeutic target
for obesity and its associated metabolic diseases. Here, we provide a brief overview of the …

Summary Background Glucocorticoids (GCs) are widely applied anti-inflammatory drugs that
are associated with adverse metabolic effects including insulin resistance and weight gain …

As a central coordinator of physiologic metabolism, adipose tissue has long been
appreciated as a highly plastic organ that dynamically responds to environmental cues …

Obesity and its complications, including type 2 diabetes, cardiovascular disease, and certain
cancers, have posed a significant burden on health and healthcare systems over the years …

The gastrointestinal system is now considered the largest endocrine organ, highlighting the
importance of gut-derived peptides and metabolites in metabolic homeostasis. Gut peptides …

Phospholipid metabolism, including phosphatidylcholine (PC) biosynthesis, is crucial for
various biological functions and is associated with longevity. Phosphatidylethanolamine N …