Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome

R Lv, X Liu, Y Zhang, N Dong, X Wang, Y He… - Signal transduction and …, 2023 - nature.com
Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …

Obstructive sleep apnea: current perspectives

AM Osman, SG Carter, JC Carberry… - Nature and science of …, 2018 - Taylor & Francis
The prevalence of obstructive sleep apnea (OSA) continues to rise. So too do the health,
safety, and economic consequences. On an individual level, the causes and consequences …

International consensus statement on obstructive sleep apnea

JL Chang, AN Goldberg, JA Alt… - International forum of …, 2023 - Wiley Online Library
Background Evaluation and interpretation of the literature on obstructive sleep apnea (OSA)
allows for consolidation and determination of the key factors important for clinical …

Phenotypes in obstructive sleep apnea: a definition, examples and evolution of approaches

AV Zinchuk, MJ Gentry, J Concato, HK Yaggi - Sleep medicine reviews, 2017 - Elsevier
Obstructive sleep apnea (OSA) is a complex and heterogeneous disorder and the apnea
hypopnea index alone can not capture the diverse spectrum of the condition. Enhanced …

Personalized management approach for OSA

JC Carberry, J Amatoury, DJ Eckert - Chest, 2018 - Elsevier
OSA is a heterogeneous disorder. If left untreated, it has major health, safety, and economic
consequences. In addition to varying levels of impairment in pharyngeal anatomy …

Apnea–hypopnea event duration predicts mortality in men and women in the sleep heart health study

MP Butler, JT Emch, M Rueschman… - American journal of …, 2019 - atsjournals.org
Rationale: Obstructive sleep apnea is a risk factor for mortality, but its diagnostic metric—the
apnea–hypopnea index—is a poor risk predictor. The apnea–hypopnea index does not …

Endotypes and phenotypes in obstructive sleep apnea

A Malhotra, O Mesarwi, JL Pepin… - Current opinion in …, 2020 - journals.lww.com
OSA is a heterogeneous disease with highly varying underlying mechanisms. OSA has
variable clinical manifestations with definable subsets having risk of particular …

More than the sum of the respiratory events: personalized medicine approaches for obstructive sleep apnea

BA Edwards, S Redline, SA Sands… - American journal of …, 2019 - atsjournals.org
Traditionally, the presence and severity of obstructive sleep apnea (OSA) have been defined
by the apnea–hypopnea index (AHI). Continuous positive airway pressure is generally first …

Recent advancements in treating sleep disorders in co-occurring PTSD

PJ Colvonen, LD Straus, C Stepnowsky… - Current psychiatry …, 2018 - Springer
Abstract Purpose of Review Comorbidity of posttraumatic stress disorder (PTSD) and
insomnia, nightmares, and obstructive sleep apnea (OSA) is high. We review recent …

Targeting endotypic traits with medications for the pharmacological treatment of obstructive sleep apnea. A review of the current literature

L Taranto-Montemurro, L Messineo… - Journal of clinical …, 2019 - mdpi.com
Obstructive sleep apnea (OSA) is a highly prevalent condition with few therapeutic options.
To date there is no approved pharmacotherapy for this disorder, but several attempts have …