The perception that intracellular lipolysis is a straightforward process that releases fatty
acids from fat stores in adipose tissue to generate energy has experienced major revisions …

Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase
superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) …

The liver is the central metabolic hub which coordinates nutritional inputs and metabolic
outputs. Food intake releases bile acids which can be sensed by the bile acid receptor FXR …

Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous
compounds, including lipid esters. Physiological functions of carboxylesterases in lipid …

Nonalcoholic fatty liver disease (NAFLD) is primarily caused by abnormal lipid metabolism
and the accumulation of triglycerides in the liver. NAFLD is also associated with hepatic …

For many years, bile acids were thought to only function as detergents which solubilize fats
and facilitate the uptake of fat-soluble vitamins in the intestine. Many early observations; …

Nonalcoholic fatty liver disease (NAFLD), a series of liver metabolic disorders manifested by
lipid accumulation within hepatocytes, has become the primary cause of chronic liver …

Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases, but its
underlying mechanism is poorly understood. Here we show that hepatocyte nuclear factor …

Non-alcoholic fatty liver disease (NAFLD) is characterized by the aberrant accumulation of
triglycerides in hepatocytes in the absence of significant alcohol consumption, viral infection …

Activation of farnesoid X receptor (FXR) markedly attenuates development of atherosclerosis
in animal models. However, the underlying mechanism is not well elucidated. Here, we …