Mechanical force matters in early T cell activation
M Fritzsche, K Kruse - Proceedings of the National Academy of Sciences, 2024 - pnas.org
Mechanical force has repeatedly been highlighted to be involved in T cell activation.
However, the biological significance of mechanical force for T cell receptor signaling …
However, the biological significance of mechanical force for T cell receptor signaling …
A dynamic biomimetic model of the membrane-bound CD4-CD3-TCR complex during pMHC disengagement
ZA Rollins, R Faller, SC George - Biophysical Journal, 2023 - cell.com
The coordinated (dis) engagement of the membrane-bound T cell receptor (TCR)-CD3-CD4
complex from the peptide-major histocompatibility complex (pMHC) is fundamental to TCR …
complex from the peptide-major histocompatibility complex (pMHC) is fundamental to TCR …
In situ cell-surface conformation of the TCR-CD3 signaling complex
A Natarajan, Y Velmurugu, M Becerra Flores… - EMBO …, 2024 - embopress.org
The extracellular molecular organization of the individual CD3 subunits around the αβ T cell
receptor (TCR) is critical for initiating T cell signaling. In this study, we incorporate photo …
receptor (TCR) is critical for initiating T cell signaling. In this study, we incorporate photo …
Revealing the Dynamic Changes Induced by Various Peptides on TCR-pMHC via Molecular Dynamics Simulation Techniques
ENB Aksoy - 2024 - search.proquest.com
Allostery, a crucial phenomenon for comprehending protein function, interactions, and
regulation, involves the transmission of perturbations induced by ligand binding to distant …
regulation, involves the transmission of perturbations induced by ligand binding to distant …