Chronic lymphocytic leukaemia (CLL), the most frequent type of leukaemia in adults, is a
lymphoproliferative disorder that is characterized by the expansion of monoclonal, mature …

Age-related alterations in the human blood system occur in B cells, T cells, cells of the innate
system, as well as hematopoietic stem and progenitor cells (HSPCs). Interestingly, age …

Natural mitochondrial DNA (mtDNA) mutations enable the inference of clonal relationships
among cells. mtDNA can be profiled along with measures of cell state, but has not yet been …

Which genetic alterations drive tumorigenesis and how they evolve over the course of
disease and therapy are central questions in cancer biology. Here we identify 44 recurrently …

Background Cancers arise from multiple acquired mutations, which presumably occur over
many years. Early stages in cancer development might be present years before cancers …

Chronic lymphocytic leukaemia (CLL) is a frequent disease in which the genetic alterations
determining the clinicobiological behaviour are not fully understood. Here we describe a …

Exosomes derived from solid tumor cells are involved in immune suppression,
angiogenesis, and metastasis, but the role of leukemia-derived exosomes has been less …

Recent investigations have provided an increasingly complete picture of the genetic
landscape of chronic lymphocytic leukaemia (CLL). These analyses revealed that the CLL …

A key feature of the adaptive immune system is the generation of memory B and T cells and
long-lived plasma cells, providing protective immunity against recurring infectious agents …

Establishing a diagnosis in patients suspected of having a myelodysplastic syndrome (MDS)
can be challenging and could be informed by the identification of somatic mutations. We …