Tumour necrosis factor (TNF) is a central cytokine in inflammatory reactions, and biologics
that neutralize TNF are among the most successful drugs for the treatment of chronic …

The mutational landscape of colorectal cancer (CRC) does not enable predictions to be
made about the survival of patients or their response to therapy. Instead, studying the …

Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered
in 1986, extraordinary efforts have been made to understand the function and regulating …

Inflammatory bowel disease (IBD) is a chronic complex inflammatory gut pathological
condition, examples of which include Crohn's disease (CD) and ulcerative colitis (UC) …

The gastrointestinal tract harbors numerous commensal bacteria, referred to as the
microbiota, that benefit host health by digesting dietary components and eliminating …

The intestinal epithelium has one of the highest rates of cellular turnover in a process that is
tightly regulated. As the transit-amplifying progenitors of the intestinal epithelium generate …

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal
tract. Cytokine-targeted therapies have transformed the treatment of IBD, providing control of …

The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory responses. NF-κB induces the …

A general consensus exists that IBD is associated with compositional and metabolic
changes in the intestinal microbiota (dysbiosis). However, a direct causal relationship …

Objective To characterise gut microbiome in patients with hepatocellular carcinoma (HCC)
and evaluate the potential of microbiome as non-invasive biomarkers for HCC. Design We …