Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

Reactive oxygen or nitrogen species (ROS/RNS) generated endogenously or in response to
environmental stress have long been implicated in tissue injury in the context of a variety of …

Summary Ischemia-reperfusion (I/R) injury is a promising therapeutic target to improve
clinical outcomes after acute myocardial infarction. Ferroptosis, triggered by iron overload …

Severe hemolysis or myolysis occurring during pathological states, such as sickle cell
disease, ischemia reperfusion, and malaria results in high levels of free heme, causing …

Transplantation of adult bone marrow–derived mesenchymal stem cells has been proposed
as a strategy for cardiac repair following myocardial damage. However, poor cell viability …

Understanding the processes governing the ability of the heart to repair and regenerate after
injury is crucial for developing translational medical solutions. New avenues of exploration …

We previously reported that intramyocardial injection of bone marrow-derived mesenchymal
stem cells overexpressing Akt (MSC-Akt) efficiently repaired infarcted rat myocardium and …

The citric acid cycle (CAC) metabolite fumarate has been proposed to be cardioprotective;
however, its mechanisms of action remain to be determined. To augment cardiac fumarate …

Background—Preeclampsia is characterized clinically by hypertension and proteinuria.
Soluble Flt-1 (sFlt-1; also known as soluble vascular endothelial growth factor receptor-1 …