Extracellular vesicles (EVs) are known mediators of intercellular communication for both
normal and tumour cells. With the capability to transfer nucleic acids, proteins and lipids …

Membrane-type matrix metalloproteases (MT-MMP) are pivotal regulators of cell invasion,
growth and survival. Tethered to the cell membranes by a transmembrane domain or GPI …

Clustering of proteins into micrometer-sized structures at membranes is observed in many
signaling pathways. Most models of clustering are specific to particular systems, and …

Macrophages represent a heterogeneous group of cells, capable of carrying out distinct
functions in a variety of organs and tissues. Even within individual tissues, their functions …

Accurate and reproducible quantification of the accumulation of proteins into foci in cells is
essential for data interpretation and for biological inferences. To improve reproducibility …

Dissemination of cancer cells from the primary tumor and their spread to distant sites of the
body is the leading cause of mortality in metastatic cancer patients. Metastatic cancer cells …

The initial step of metastasis is the local invasion of tumor cells into the surrounding tissue.
Invadopodia are actin-based protrusions that mediate the matrix degradation necessary for …

Artificial Intelligence (AI) has emerged as a transformative tool in predicting metastasis risk
and survival outcomes in cancer care. Traditional methods for assessing cancer progression …

Abstract Background Annexin A1 (ANXA1), a 37 kDa multifunctional protein, is over-
expressed in tissues from patients of pancreatic carcinoma (PC) where the protein seems to …

We have previously shown that lipoma preferred partner (LPP) mediates TGFβ-induced
breast cancer cell migration and invasion. Herein, we demonstrate that diminished LPP …