Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …

α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve
terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) …

Neurodegeneration is the pathological condition, in which the nervous system or neuron
loses its structure, function, or both, leading to progressive degeneration or the death of …

The levels and conformers of alpha‐synuclein are critical in the pathogenesis of Parkinson's
Disease and related synucleinopathies. Homeostatic mechanisms in protein degradation …

Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are common
neurodegenerative disorders of the aging population, characterized by progressive and …

α-Synuclein (αsyn) is an abundant brain neuronal protein that can misfold and polymerize to
form toxic fibrils coalescing into pathologic inclusions in neurodegenerative diseases …

An increasing wealth of data indicates a close relationship between the presynaptic protein
alpha-synuclein and Parkinson's disease (PD) pathogenesis. Alpha-synuclein protein levels …

A better understanding of the molecular and cellular determinants that influence the
pathology of Parkinson's disease (PD) is essential for developing effective diagnostic …

Neurodegeneration is a chronic progressive loss of neuronal cells leading to deterioration of
central nervous system (CNS) functionality. It has been shown that neuroinflammation …

Adaption of a single protein to perform multiple independent functions facilitates functional
plasticity of the proteome allowing a limited number of protein-coding genes to perform a …