Advancing cell-based cancer immunotherapy through stem cell engineering
Advances in cell-based therapy, particularly CAR-T cell therapy, have transformed the
treatment of hematological malignancies. Although an important step forward for the field …
treatment of hematological malignancies. Although an important step forward for the field …
Understanding adipocyte differentiation
FM Gregoire, CM Smas, HS Sul - Physiological reviews, 1998 - journals.physiology.org
Gregoire, Francine M., Cynthia M. Smas, and Hei Sook Sul. Understanding Adipocyte
Differentiation. Physiol. Rev. 78: 783–809, 1998.—The adipocyte plays a critical role in …
Differentiation. Physiol. Rev. 78: 783–809, 1998.—The adipocyte plays a critical role in …
T-cell development and the CD4–CD8 lineage decision
RN Germain - Nature reviews immunology, 2002 - nature.com
Cell-fate decisions are controlled typically by conserved receptors that interact with co-
evolved ligands. Therefore, the lineage-specific differentiation of immature CD4+ CD8+ T …
evolved ligands. Therefore, the lineage-specific differentiation of immature CD4+ CD8+ T …
Deficient T cell fate specification in mice with an induced inactivation of Notch1
F Radtke, A Wilson, G Stark, M Bauer, J van Meerwijk… - Immunity, 1999 - cell.com
Notch proteins are cell surface receptors that mediate developmental cell specification
events. To explore the function of murine Notch1, an essential portion of the gene was …
events. To explore the function of murine Notch1, an essential portion of the gene was …
The emerging role of ADAM metalloproteinases in immunity
BN Lambrecht, M Vanderkerken… - Nature Reviews …, 2018 - nature.com
Proteolysis is an irreversible physiological process that can result in the termination or
activation of protein function. Many transmembrane proteins that are involved in the cellular …
activation of protein function. Many transmembrane proteins that are involved in the cellular …
Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1
Alagille syndrome is an autosomal dominant disorder characterized by abnormal
development of liver, heart, skeleton, eye, face and, less frequently, kidney. Analyses of …
development of liver, heart, skeleton, eye, face and, less frequently, kidney. Analyses of …
Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro
TM Schmitt, JC Zúñiga-Pflücker - Immunity, 2002 - cell.com
The molecular interactions provided by the thymic microenvironment that predicate T cell
development remain obscure. Here, we show that a bone marrow stromal cell line …
development remain obscure. Here, we show that a bone marrow stromal cell line …
Mammalian glycosylation in immunity
JD Marth, PK Grewal - Nature Reviews Immunology, 2008 - nature.com
Glycosylation produces a diverse and abundant repertoire of glycans, which are collectively
known as the glycome. Glycans are one of the four fundamental macromolecular …
known as the glycome. Glycans are one of the four fundamental macromolecular …
An overview of the intrathymic intricacies of T cell development
DK Shah, JC Zúñiga-Pflücker - The Journal of Immunology, 2014 - journals.aai.org
The generation of a functional and diverse repertoire of T cells occurs in the thymus from
precursors arriving from the bone marrow. In this article, we introduce the various stages of …
precursors arriving from the bone marrow. In this article, we introduce the various stages of …
Notch signaling: the core pathway and its posttranslational regulation
ME Fortini - Developmental cell, 2009 - cell.com
Notch signaling controls numerous cell-fate specification events in multicellular organisms,
and dysregulated Notch signaling causes several diseases with underlying developmental …
and dysregulated Notch signaling causes several diseases with underlying developmental …