Exploring the mechanical perspective of a new anti-tumor agent: melatonin

S Rohilla, M Singh, S Priya, WH Almalki… - Journal of …, 2023 - dl.begellhouse.com
Melatonin is a serotonin-derived pineal gland hormone with many biological functions like
regulating the sleep-wake cycle, circadian rhythm, menstrual cycle, aging, immunity, and …

Matrine: a promising natural product with various pharmacological activities

H Zhang, L Chen, X Sun, Q Yang, L Wan… - Frontiers in …, 2020 - frontiersin.org
Matrine is an alkaloid isolated from the traditional Chinese medicine Sophora flavescens
Aiton. At present, a large number of studies have proved that matrine has an anticancer …

In vitro and in vivo anticancer effects of syringic acid on colorectal cancer: Possible mechanistic view

A Mihanfar, SG Darband, S Sadighparvar… - Chemico-Biological …, 2021 - Elsevier
This study aimed to evaluate the in vitro effects of syringic acid on human colorectal cancer
cells (SW-480) and the effect of orally administered syringic acid on in vivo models of …

Neuroprotection of melatonin on spinal cord injury by activating autophagy and inhibiting apoptosis via SIRT1/AMPK signaling pathway

K Gao, J Niu, X Dang - Biotechnology letters, 2020 - Springer
The effect of melatonin (MT) on spinal cord injury (SCI) has attracted increasing research
attention. However, the specific role and molecular mechanism of MT on SCI have not been …

Melatonin: an important anticancer agent in colorectal cancer

M Mirza‐Aghazadeh‐Attari… - Journal of cellular …, 2020 - Wiley Online Library
Colorectal cancer is one of the most common cancers among the elderly, which is also seen
in the forms of hereditary syndromes occurring in younger individuals. Numerous studies …

Rafoxanide promotes apoptosis and autophagy of gastric cancer cells by suppressing PI3K/Akt/mTOR pathway

JZ Liu, YL Hu, Y Feng, YB Guo, YF Liu, JL Yang… - Experimental cell …, 2019 - Elsevier
Rafoxanide is commonly used as anti-helminthic medicine in veterinary medicine, a main
compound of salicylanilide. Previous studies have reported that rafoxanide, as an inhibitor of …

Research progress of sophoridine's pharmacological activities and its molecular mechanism: an updated review

Y Chen, X Wang, D Ye, Z Yang, Q Shen… - Frontiers in …, 2023 - frontiersin.org
Background: Sophoridine, the major active constituent of Sophora alopecuroides and its
roots, is a bioactive alkaloid with a wide range of pharmacological effects, including …

Regulation of autophagy by microRNAs in human breast cancer

ZX Chong, SK Yeap, WY Ho - Journal of Biomedical Science, 2021 - Springer
Breast cancer is the most common solid cancer that affects female population globally.
MicroRNAs (miRNAs) are short non-coding RNAs that can regulate post-transcriptional …

Inhibition of hsa_circ_0003489 shifts balance from autophagy to apoptosis and sensitizes multiple myeloma cells to bortezomib via miR‐874‐3p/HDAC1 axis

FQ Tian, ZR Chen, W Zhu, MQ Tang… - The Journal of Gene …, 2021 - Wiley Online Library
Abstract Background Circular RNAs (circRNAs) crucially regulate tumor progression. In this
study, we examined the functional roles and mechanisms of hsa_circ_0003489 in multiple …

Potential role of melatonin in prevention and treatment of lung cancer

ZN Ngai, KC Chok, KY Ng, RY Koh… - … Molecular Biology and …, 2022 - degruyter.com
Lung cancer is the second most common cancer and the most lethal cancer worldwide.
Melatonin, an indoleamine produced in the pineal gland, shows anticancer effects on a …