Formation of distant metastases is by far the most common cause of cancer-related deaths.
The process of metastasis formation is complex, and within this complex process the …

The ADAMs family of transmembrane proteins belongs to the zinc protease superfamily.
Members of the family have a modular design, characterized by the presence of …

OBJECTIVE: Cancer cells in the body release soluble and membranous factors that
manipulate the tumor environment to facilitate growth and survival. Recent years have …

KIM-1 (kidney injury molecule-1) is a type I transmembrane glycoprotein expressed on
dedifferentiated renal proximal tubule epithelial cells undergoing regeneration after toxic or …

Matrix metalloproteinases (MMPs) constitute a family of more than 20 endopeptidases.
Identification of specific matrix and non-matrix components as MMP substrates showed that …

L1 cell adhesion molecule (L1CAM) is one of the first neural adhesion molecules described
with important functions in the development of the nervous system. Subsequent work …

The L1 cell adhesion molecule (L1CAM) plays a major role in the development of the
nervous system and in the malignancy of human tumors. In terms of biological function …

The L1 adhesion molecule plays an important role in axon guidance and cell migration in
the nervous system. L1 is also expressed by many human carcinomas. In addition to cell …

EMMPRIN is a transmembrane glycoprotein expressed at high levels by tumor cells. It has
been identified as a tumor-derived factor that can stimulate matrix metalloproteinase …

Background Ovarian and uterine carcinomas are the most common cause of cancer-related
deaths in gynecological malignant diseases. We aimed to assess whether the L1 adhesion …