The expansion of repeated sequences is the cause of over 30 inherited genetic diseases,
including Huntington disease, myotonic dystrophy (types 1 and 2), fragile X syndrome, many …

Microsatellites are a ubiquitous class of simple repetitive DNA sequences, which are
widespread in both eukaryotic and prokaryotic genomes. The use of microsatellites as …

Transcription stimulates the genetic instability of trinucleotide repeat sequences. However,
the mechanisms leading to transcription-dependent repeat length variation are unclear. We …

Substantial progress has been realized in the past several years in our understanding of the
molecular mechanisms responsible for the expansions and deletions (genetic instabilities) …

DNA mismatch repair is a conserved antimutagenic pathway that maintains genomic stability
through rectification of DNA replication errors and attenuation of chromosomal …

Friedreich ataxia, the most common in herited ataxia, is caused by the transcriptional
silencing of the FXN gene, which codes for the 210 amino acid frataxin, a mitochondrial …

Large-scale expansions of DNA repeats are implicated in numerous hereditary disorders in
humans. We describe a yeast experimental system to analyze large-scale expansions of …

Alterations in the length (instability) of gene-specific microsatellites and minisatellites are
associated with at least 35 human diseases. This review will discuss the various cis …

Comparative genome analyses of close relatives have yielded exciting insight into the
sources of microbial genome variability with respect to gene content, gene order and …

Several molecular mechanisms have been proposed to explain trinucleotide repeat
expansions. Here we show that in yeast srs2 Δ cells, CTG repeats undergo both expansions …