Emerging computational approaches for antimicrobial peptide discovery

G Agüero-Chapin, D Galpert-Cañizares… - Antibiotics, 2022 - mdpi.com
In the last two decades many reports have addressed the application of artificial intelligence
(AI) in the search and design of antimicrobial peptides (AMPs). AI has been represented by …

Different DNA sequencing using DNA graphs: A study

AM Alanazi, G Muhiuddin, DA Al-Balawi, S Samanta - Applied Sciences, 2022 - mdpi.com
Natural genetic material may shed light on gene expression mechanisms and aid in the
detection of genetic disorders. Single Nucleotide Polymorphism (SNP), small insertions and …

Complex networks analyses of antibiofilm peptides: an emerging tool for next-generation antimicrobials' discovery

G Agüero-Chapin, A Antunes, JR Mora, N Pérez… - Antibiotics, 2023 - mdpi.com
Microbial biofilms cause several environmental and industrial issues, even affecting human
health. Although they have long represented a threat due to their resistance to antibiotics …

Non-standard bioinformatics characterization of SARS-CoV-2

D Bielińska-Wąż, P Wąż - Computers in biology and medicine, 2021 - Elsevier
A non-standard bioinformatics method, 4D-Dynamic Representation of DNA/RNA
Sequences, aiming at an analysis of the information available in nucleotide databases, has …

Putative Antimicrobial Peptides of the Posterior Salivary Glands from the Cephalopod Octopus vulgaris Revealed by Exploring a Composite Protein Database

D Almeida, D Domínguez-Pérez, A Matos… - Antibiotics, 2020 - mdpi.com
Cephalopods, successful predators, can use a mixture of substances to subdue their prey,
becoming interesting sources of bioactive compounds. In addition to neurotoxins and …

Omics and remote homology integration to decipher protein functionality

L Silva, A Antunes - Homology Modeling: Methods and Protocols, 2023 - Springer
In the recent years, several “omics” technologies based on specific biomolecules (from DNA,
RNA, proteins, or metabolites) have won growing importance in the scientific field. Despite …

Unveiling Encrypted Antimicrobial Peptides from Cephalopods' Salivary Glands: A Proteolysis-Driven Virtual Approach

G Agüero-Chapin, D Domínguez-Pérez… - 2023 - chemrxiv.org
Antimicrobial peptides (AMPs), with their versatile actions, offer promise against
antimicrobial resistance and as templates for novel therapeutic agents. While existing AMP …

4D-Dynamic Representation of DNA/RNA Sequences: Studies on Genetic Diversity of Echinococcus multilocularis in Red Foxes in Poland

D Bielińska-Wąż, P Wąż, A Lass, J Karamon - Life, 2022 - mdpi.com
The 4D-Dynamic Representation of DNA/RNA Sequences, an alignment-free bioinformatics
method recently developed by us, has been used to study the genetic diversity of …

A Comparative Analysis of Transformer-based Protein Language Models for Remote Homology Prediction

A Kabir, A Moldwin, A Shehu - Proceedings of the 14th ACM International …, 2023 - dl.acm.org
Protein language models based on the transformer architecture are increasingly shown to
learn rich representations from protein sequences that improve performance on a variety of …

Model Formalization for Genomes Comparative Analysis Using a Graph Database

DE Rusinova, YV Stroganov - 2022 Conference of Russian …, 2022 - ieeexplore.ieee.org
The paper aims to discuss the problem of graph data model formalization for genomic
information representation. The model being discussed is designated for the implementation …